尿中性粒细胞明胶酶相关脂质运载蛋白检测在糖尿病患者肾功能损伤早期诊断中的价值

Significance of urine neutrophil gelatinase associated lipocalin in early diagnosis of renal dysfunction for patients with diabetes

目的探讨尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)在糖尿病患者肾功能损伤早期诊断中的价值。方法选择在湖南省益阳医学高等专科学校附属医院住院治疗的患糖尿病并伴有早期肾功能损伤的患者66例为实验组,同期住院且排除慢性肾病、高血压病等影响肾功能疾病的单纯糖尿病患者60例为对照组,分别测定其尿NGAL、血清半胱氨酸蛋白酶抑制剂C(Cys-C)、尿素氮(BUN)及肌酐(Cr)水平,并进行对比分析。结果实验组尿NGAL水平明显高于对照组,差异具有统计学意义(P<0.05),实验组血清Cys-C、BUN及Cr水平与对照组比较,差异无统计学意义(P>0.05)。结论尿NGAL是检测糖尿病患者早期肾功能损伤的敏感指标之一。

Objective To discuss the significance of urine neutrophil gelatinaseassociated lipocalin（NGAL） in early diagnosis of renal dysfunction for patients with diabetes. Metllods 66 patients with diabetes and early renal dysfunction who received the treatment in our hospital were in the experimental group ; while 60 diabetic patients without the chronic kidney disease or hypertension that could affect the renal function were in the control group. The levels of urine NGAL,Cystatin C（Cys-C） ,blood urea nitrogen（BUN） and creatinine（Cr） were measured respectively and taken for the comparative analysis. Results The level of urine NGAL in the experimental group was significantly higher than the one in the control group, with value of 18. 262 5 and statistically significant difference（P〈0.05）; compared to the control group,t values of Cys-C,BUN and Cr in the experimental group were 1. 655 4,1. 808 5 and 1. 574 1 respectively（P〉0.05）. The difference was not statically significant. Conclusion The urine NGAL is one of sensitivity indices to monitor the early renal dysfunction for patients with diabetes.