118株肠杆菌科病原菌分布及耐药分析

The drug sensitivity analysis of 118 pathogens of enterobacteriaceae

目的了解湖北省罗田县人民医院肠杆菌科病原菌分布及耐药现状。方法对2011年1～12月分离的118株肠杆菌科病原菌株,选用13种常用抗菌药物,进行体外药敏试验,观察大肠埃希菌和肺炎克雷伯菌是否产超广谱β-内酰胺酶(ESBLs)。结果118株肠杆菌科菌以大肠埃希菌为主,分布为大肠埃希菌56.78%(67/118),肺炎克雷伯菌25.42%(30/118),肠杆菌属17.80%(21/118)。118株肠杆菌科病原菌对常用抗菌药物均有较高的耐药性。结论临床应合理使用抗菌药物,减少耐药菌株产生,避免医源性感染。

Objective To explore the region and drug resistance of pathogens. Methods 118 pathogens of en- terobacteriaceae were separated from January 2011 to December 2011. We selected 13 common antibiotic drug to do chemosensitivity assay in vitro and observed E. coil and Klebsiella pneumoniae ESBLs detection rate. Results The E. coil was chief enterobacteriaceae. The bacterial flora distribution showed： the ESBLs detection rate of E. coil was 67/118（56.78%） ,Klebsiella pneumoniae was 30/118（25.42%） ,Enterobacter was 21/118（17.8%）. The drug sensi- tive test showed： 118 pathogens of enterohacteriaceae were highly resistant to drugs for common antibiotic drug. Conclusion It should rationally use antibiotics, reduce drug resistance strains and avoid the medical source infection.