转载蛋白E与同型半胱氨酸和胱抑素C联合检测对糖尿病合并血管病变的诊断价值

Clinical diagnostic evaluation of APO-E,Hcy,CysC Joint detection on DM merger vascular lesions

目的探讨糖尿病(DM)患者转载蛋白E(APO-E)、同型半胱氨酸(Hcy)、胱抑素C(CysC)动态变化与并发血管病变的关系。方法对健康人、无糖尿病的冠心病和脑动脉硬化患者、有糖尿病的冠心病和脑动脉硬化患者进行总循环血红蛋白量(Tch)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、APO-E、Hcy、Cy-sC项目的测定。测定仪器为Hitachi7600全自动生化分析仪,试剂、校准品及质控品与测定仪器配套。对影响DM患者合并血管病变的危险因素进行Logistic多元回归分析。结果病变各组TG、LDL、APO-E、Hcy、CysC值差异有统计学意义(P<0.05),其中DM各病变组Hcy、CysC测定值及阳性率与健康对照组比,差异有统计学意义(P<0.05)。结论 TG、LDL、Hcy、CysC是DM患者大血管病变发生的危险因素。

Objective To prove the relationship between dynamic changes of diabetes mellitus（DM） patients＇ apolipoprotein E（APO-E） ,homocysteine（Hcy） ,Cystatin C（CysC） and concurrent vascular lesions. Methods Quantitative assays of Triglyceride（TG）, high density lipoprotein（HDL）, low density lipoprotein（LDL）, APO-E, Hcy, Cy sC of normal people and patients with coronary heart disease and brain arterial sclerosis with and without diabetes were done. Measuring instruments was HITACHI7600 automatic biochemistry analyzer, reagent calibration product, the quality product were measuring instruments supporting. The impact of DM patients with vascular lesions of the dangerous factors were analyzed for logistic regression analysis,. Results The values of TG,APO, LDL, Hey,APO- E,CysC were statistically significant,among them, the values Hcy, CysC and positive rates had statistically significant difference between in DM group. Conclusion LDL, Hcy,CysC,TG are big happened risk factors in DM patients with vascular lesions.