机械通气相关性肺损伤中α7烟碱型乙酰胆碱受体的作用和机制

The role and mechanism of α7-nicotinic acetylcholine receptors in ventilation-induced lung injury

背景机械通气是治疗急性肺损伤（acutelunginjury，ALI）和急性呼吸窘迫综合征（acuterespiratorydistresssyndrome，ARDS）的必要措施，但同时又增加了机械通气相关性肺损伤（ventilation_inducedlunginjury，VKKI）的发病率。而胆碱能抗炎通路是近年来发现的一种通过传出迷走神经来抑制炎症的神经．内分泌抗炎途径，其主要通过饯7烟碱型乙酰胆碱受体（ct7nicotinicacetylcholinereceptorstype，α7nAChR）发挥作用。目的对α7nAChR在VILI中的作用和机制的研究进展进行回顾和总结。内容共4部分：①VILI研究现状与共识；②胆碱能抗炎通路的研究进展；③α7nAChR在VILI中的具体机制；④归纳总结。趋向α7nAChR在VILI中的作用和机制错综复杂，弄清这些复杂的信号转导机制对于揭示VILI的发生机制和预防VILI的发生具有临床意义。

Background Mechanical ventilation is a necessaryand useful treatment of acute lung injury （ALI） And acute respiratory distress syndrome （ARDS）. But at the same time mechanical ventilation will induce lung injury （ventilation induced lung injury, VILI）. And cholinergic Anti-inflammatory Pathway is found in recent years. It is a kind of spread through the vagus nerve to curb inflammation of nerve-endocrine anti-inflammatory way. And play a crucial role by α7 nicotinic acetylcholine receptors type （α7 nAChR）. Objective This review highlights the advance in mechanism of α7nAChR in VILI, summarizing current best evidenceing on its clinical application. Content Our review will be divided into four parts： The state of the art and consensus in VILI. Study progress of cholinergic anti-inflammatory pathway. The role and mechanism of α7nAChR in VILI. Sum up. Trend The cardioprotective mechanisms of α7nAChR in VILI are complicated. Fully understand these complex mechanisms of signal transduction will be helpful to illuminate the principle and promote its clinical application.