微小RNA在病理性疼痛中的作用

The role of microRNAs in pathological pain

背景微小RNA（micmRNAs，miRNAs）是目前研究最为广泛的一类内源性非编码小分子RNA，长度范围在16～29个核苷酸之间，通过转录后调节机制调节基因的表达。最近研究发现miRNAs在不同的病理性疼痛模型中均有不同程度的表达，可能参与慢性疼痛以及急性伤害性刺激伤害感受过程的基因调节机制，调控几种与疼痛相关转录物的表达。目的对miRNAs在病理性疼痛中作用的研究有助于我们更清楚地了解病理性疼痛的产生和维持分子学机制，为疼痛治疗提供了新的方向。内容主要介绍miRNAs在炎症性痛、神经病理性痛以及疼痛相关性疾病中的表达情况，以及miRNAs在慢性病理性疼痛中的可能作用。趋势鉴于miRNAs在病理性疼痛的产生中具有重要作用，miRNAs将有可能作为治疗疼痛性疾病的一种新型的研究工具、生物标记和潜在的药物治疗靶点。

Background MicroRNAs （miRNAs） are the most widely studied class of endogenous non-protein-coding small RNA molecules, length 16-29 nucleotides that regulate gene expression through post-transcriptional regulatory mechanisms. Extensive studies have proved that there are different levels of expression of miRNAs in different neuropathic pain model, miRNAs may be involved in gene regulation mechanisms of chronic pain and acute noxious stimulation of nociceptive processes, miRNAs regulation of several pain-related transcript expression. Objective The study of role of miRNAs in pathological pain will help us to understand generation and maintenance molecular mechanisms of pathological pain clearer, miRNAs may be a new direction for the treatment of pain. Content This article introduces the expression of miRNAs in inflammatory pain, neuropathic pain models, and pain-related diseases, as well as the possible role of miRNAs in chronic pathological pain. Trend View of the importment role of miRNAs in the pathological pain, miRNAs will be novel biomarkers for the treatment of painful diseases, and potential drug therapeutic targets.