妊娠期高血压疾病患者凝血和抗凝因子的变化及意义

Change and significance of coagulation factors and anti-coagulation factors in patients with hypertensive disorder complicating pregnancy

目的:探讨妊高征患者凝血和抗凝因子的变化及意义。方法:采用STA-R自动血凝仪分别检测80例妊娠期高血压疾病患者(妊高征组)、25例正常孕妇(对照组)的凝血因子Ⅷ:C、Ⅸ:C、AT(抗凝血酶):C及VWF(血小板表面受体)抗原含量。结果:妊高征组凝血因子Ⅷ:C、Ⅸ:C及VWF:Ag均明显高于对照组(P<0.05或P<0.01);妊高征组AT:C明显低于对照组(P<0.05或P<0.01)。结论:检测凝血因子Ⅷ:C、Ⅸ:C、AT:C及VWF:Ag对诊治妊高征有一定的临床意义。

Objective： To explore the change and significance of coagulation factors and anti -coagulation factors in patients with hypertensive disorder complicating pregnancy （HDCP） . Methods： The contents of coagulation factors VIII： C, IX： C, AT： C, and VWF： Ag of 80 patients with HDCP （HDCP group） and 25 normal pregnant women （control group） were detected by STA -R automatic blood coagulation meter. Results： The contents of coagulation factors Vi ： C, IX ： C, and VWF ： Ag in HDCP group were higher than those in control group （ P 〈 0. 05 or P 〈 0.01 ） ; while the content of AT ： C in HDCP group was lower than that in control group （ P 〈 0. 05 or P 〈 0.01 ） . Conclusion： Detecting coagulation factors VII： C, IX： C, AT： C, and VWF： Ag has a certain clinical significance for diagnosis and treatment of HDCP.