原发性醛固酮增多症的内分泌功能诊断

Endocrine functional diagnosis in primary aldosteronism

原发性醛固酮增多症（原醛症）是继发性高血压最常见的原因之一，以低肾素和高醛固酮血症为特征，血浆醛固酮／肾素比值（ARR）是筛查原醛症的可靠指标。而口服高钠负荷试验、生理盐水试验、氟氯可的松抑制试验或卡托普利试验中的任何一项均可作为ARR阳性患者的确诊试验；肾上腺静脉插管采血（AVS）是原醛症分型诊断的金标准。

Primary aldosteronism is one of the most common causes of secondary hypertension, which is characterized by low plasma renin and high aldosterone, and a major reliable tool for screening primary aldosteronism is the plasma aldosterone/renin activity ratio （ARR）. Any of the four confirmatory tests such as oral sodium loading, intravenous saline infusion, captopril challenge and fludrocortisone administration plus sodium loading may carry out in patients who have positive ARR. And adrenal vein sampling （AVS） is recommended as the golden standard to diagnose primary aldosteronism.