地奥司明片减轻肛门直肠手术后水肿、疼痛和促进创面愈合的临床观察

Clinical Observation of Edema and Pain Relief and Wound Healing by Diosmin Tablets after Anorectal Operation

目的:观察地奥司明片减轻肛门直肠手术后水肿、疼痛和促进创面愈合的临床效果。方法:将我院2011年3-9月260例行肛门直肠手术患者随机分为治疗组(136例)和对照组(124例)。治疗组术后第1天开始服用地奥司明片,每次2片(每片0.45g),每日2次,连服7d;对照组术后不口服地奥司明片及其他止痛、消炎药物。对2组患者术后创面局部水肿和疼痛情况及创面愈合时间进行比较,并观察不良反应。结果:治疗组术后48、72h和7d的水肿和疼痛评分及总评分较对照组显著改善(P<0.01);治疗组术后平均创面愈合时间显著短于对照组(P<0.01)。2组患者均未见不良反应发生。结论:地奥司明片能有效减轻患者肛门直肠手术后水肿和疼痛症状,促进创面愈合,且安全性较好。

OBJECTIVE： To observe the clinical efficacy of edema and pain relief and wound healing by Diosmin tablets after anorectal operation. METHODS： 260 patients underwent anorectal operation in our hospital during Mar. - Spet. 20tl were randomized into treatment group （136 cases） and control group （124 cases）. Treatment group was given Diosmin tablets 2 pieces each time （0.45 g per piece） twice a day for consecutive 7 days since first day after operation; control group didn＇t taken Diosmin tablets and any analgesic and anti-inflammatory drugs. Local edema and pain and time of wound healing were compared between 2 groups after treatment, and adverse drug reaction was observed. RESULTS： The edema and pain score and total score of treatment group were improved significantly 48 h, 72 h and 7 d after operation, compared with control group （P〈0.01） ; average time of wound healing in treatment group was shorter than in control group significantly （P〈0.01）. No obvious ADR was found in 2 groups. CONCLUSION： Diosmin tablet is effective and safe in the treatment of edema and pain after anorectal operation and pro- mote wound healing.