摘要
两栖动物的幼体变态是研究甲状腺激素调节组织和器官重构的理想模式。本文主要综述了近年来两栖动物甲状腺激素合成过程中3种脱碘酶D1、D2和D3的特点及其生物学功能;甲状腺激素受体的蛋白结构、类型和机能;以及甲状腺激素对两栖动物幼体变态过程中各个类型组织和器官重构的调节;甲状腺激素、甲状腺激素受体和脱碘酶的互作,并展望了今后的研究方向。
Amphibian metamorphosis is an ideal model system to understand the action of the thyroid hormone (TH) on the remolding of tissue and organ. Firstly, the characteristics and functions of three types of deiodinases are reviewed. Emphasis is laid on the structure, the types and functions of thyroid hormone receptors. The remolding of tissue and organ in amphibian metamorphosis regulated by TH is described. Meanwhile, interactions among TH, deiodinase and thyroid hormone receptors in amphibian metamorphosis are discussed. Finally, future perspectives for amphibian metamorphosis studies are proposed.
出处
《动物学杂志》
CAS
CSCD
北大核心
2012年第6期136-143,共8页
Chinese Journal of Zoology
基金
中央高校基本科研业务费专项资金项目(No.GK261001)
关键词
甲状腺激素
甲状腺激素受体
两栖动物变态
Thyroid hormone
Thyroid hormone receptors
Amphibian metamorphosis