摘要
阿尔茨海默病(Alzheimer’s disease,AD)是一种以不可逆的记忆力进行性减退直至痴呆为特征的神经变性疾病,伴随认知减退及视觉空间感觉的丧失。目前国内外有文献表明可对某些特殊蛋白如β-淀粉样蛋白、细胞型朊蛋白进行分子生物学实验,发现它们会影响AD的发展,并且称可通过眼科光学相干断层成像技术完善AD的早期诊断。现就β-淀粉样蛋白、细胞型朊蛋白分别对AD及视神经的影响作一综述。同时,基于AD患者有视网膜机能失调,还就上述两种蛋白与AD视神经的关系作了初步展望。
Alzheimer＇ s disease（AD） is a kind of neural degeneration disease with irreversible decreased memory until the dementia, associated with cognitive decline and loss of visual space perception. Nowadays, domestic and foreign literatures indicated that some special proteins, such as β-amyldid, cellular prion protein, affected the devel- opment of AD in molecular biology experiments, and the literatures also suggested that the early diagnosis of AD could be improved by ophthalmic optical coherence tomo- graphy. This article reviews the effects of [3-amyloid and cellular prion protein on AD and optic nerve. At the same time, based on the retinal dysfunction in AD patients, the relationship between above two proteins and AD optic nerve relationship is primary loo- king ahead.
出处
《眼科新进展》
CAS
北大核心
2012年第12期1194-1196,共3页
Recent Advances in Ophthalmology
