长期饮酒对老年人认知损害和脑萎缩的影响及其相关性的探讨

Effect of long-term drinking on cognitive impairment and brain atrophy of senior citizens and correlation analysis.

目的评估长期饮酒对老年人认知功能损害和脑萎缩的影响,探讨其认知功能损害与脑萎缩的相关性。方法分别应用剑桥老年认知量表中文版(CAMCOG-C)对56例长期饮酒老年人(饮酒组)和58名匹配的健康对照组进行认知功能评定,全部对象行脑CT检查。比较两组间的差异,并对其相关性进行分析。结果饮酒组CAMCOG-C总分及各项亚测试评分均显著低于对照组(P<0.05)。饮酒组脑萎缩发生率明显高于对照组(P<0.01)。脑萎缩者认知功能障碍发生率明显高于无脑萎缩者(P<0.01)。结论长期大量饮酒者存在明显的认知功能损害及脑结构异常,两者存在一定的相关性。

Objective To evaluate the effect of long-term drinking on the cognitive impairment and brain atrophy of senior citizens, and to discuss the correlation between cognitive impairment and brain atrophy. Methods Chinese version of Cambridge Cognitive Examination （CAMCOG-C） was applied to evaluate the cogni- tive fimctions of 56 senior citizens with long-term drinking （the study group） and the 58 matched healthy senior citi- zens （the control group）. All the citizens were examined by brain CT. The correlation between cognitive impairment and brain atrophy were analyzed. Results The aggregate scores and scores of various sub-tests of the study group were obviously lower than in the control group （P〈0.05）. The incidence of brain atrophy of the study group was signif- icantly higher than that of the control group （P〈0.01）. The incidence of cognitive dysfunction among people suffering from brain atrophy was significantly higher than that of people without brain atrophy. Conclusion People who have drunk a lot for a long term often suffer from significant cognitive impairment and brain structural abnormalities. And certain correlation exists between the cognitive impairment and brain structural abnormalities.