VEGF—C、CD24在肺癌组织的表达及临床意义

The expression and clinical significance of VEGF-C and CD24 in lung cancer

目的探讨VEGF—C、CD24在肺癌组织中的表达及其临床意义。方法采用RT—PCR和免疫组化方法检测138例原发性肺癌患者肿瘤组织及癌旁组织中VEGF—C、CD24的表达水平。结果（1）肺癌组织中VEGF—C、CD24mRNA及蛋白的表达均高于癌旁组织（P〈0．05），两者在肺癌组织中的表达明显正相关（P〈0．05）；（2）有淋巴结转移组中VEGF—C、CD24mRNA及蛋白的阳性表达量均高于无淋巴结转移组（P〈0．05）；（3）VEGF—C、CD24表达与淋巴结转移、肿瘤TNM分期等临床病理特征间有明显相关性（P〈0．05）；（4）VEGF—C、CD24蛋白表达与ⅢA期患者的短期预后有关，两者的mRNA水平与无病生存时间呈负相关。结论VEGF—C、CD24在肺癌组织中均异常表达，可作为肺癌诊断的辅助标志物。

Objective To study the expressions of VEGF-C and CD24 in lung cancer and their clinical significance, and to discuss the relationship between their expressions as well. Methods The methods of RT-PCR and immunohistoehemieal staining are adopted. The expression levels of VEGF-C, CD24 mRNAs and proteins in 138 primary lung cancer patients＇cancer tissues and paraeanccrous tissues are detected. Results （ 1 ） The expression levels of VEGF-C, CD24 mRNA and proteins in lung cancer tissues are all higher than those in paracancerous tissues （P 〈 0.05 ）. There is evident positive correlativity between the expressions of VEGF-C and CD24 in lung cancer（ P 〈 0.05 ） （2） The expression levels of VEGF-C, CD24 mRNA and pro- teins in the metastasis group are all higher than those in the non-metastasis group （P 〈 0.05 ）. （3） There is evident correlativity between the expression of VEGF-C, CD24 and lymph node metastasis, TNM staging（ P 〈 0.05 ）. （4） The expressions of VEGF-C, CD24 mRNA and proteins are both related to the short-term prognosis of the Stage Ilia patients. Conclusion VEGF-C and CD24 are both abnormally expressed in lung cancer tissues, which can be used as a marker of lung cancer diagno-