IL-2、IL-10在口腔扁平苔藓发病中的作用

The role of IL-2/IL-10 cell in the pathogenesis of oral lichen planus

目的:通过对口腔扁平苔藓(OLP)局部组织及外周血中IL-2、IL-10表达进行研究,进一步探讨OLP发病机制。方法:应用免疫组织化学SABC法检测30例OLP中IL-2、IL-10的表达数量及分布,同时用ELISA法检测外周血中IL-2、IL-10的含量。结果:①在病损组织中,OLP组中IL-2、IL-10表达显著高于对照组(P<0.05)。IL-2主要分布在淋巴细胞浸润带,在基底膜附近较集中;IL-10主要分布在固有层,远离基底膜。②在外周血中,糜烂型OLP组IL-2、IL-10含量明显高于对照组和非糜烂型OLP组(P<0.05)。结论:①根据IL-2、IL-10在OLP中表达和分布情况,提示IL-2、IL-10在OLP发病机制中参与了机体免疫的调节和介导作用。②外周血中IL-10高表达,提示糜烂型OLP患者全身的免疫反应参与了本病的形成或可能伴有全身免疫系统功能紊乱。

Objective：To evaluate the expression of IL-2, IL-IO in oral lichen planus （OLP） and to evaluate the possible pathogenesis of oral lichen planus. Method： Immunohistochemical technique was employed to study the expression of IL-2, IL-10 in oral mucosa and ELASA was used for detecting the contents of IL-2, IL-IO in peripheral blood of 30 OLP cases. Result： The expression of IL-2, IL-10 were significantly increased in OLP compared with that in NOM （P 〈0.05）. IL- 2 was mainly localized in the lymphocytic infiltration, focus on the basal cell membrane and IL-10 was mainly localized in lamina propria separately. The amount of IL-10 was obviously elevated in erosion OLP peripheral blood compared with the non-erosion and NOM （P 〈0.05）. Conclusion： The increasing expression of IL-2, IL-10 has also explained the association of these cytokines with Local anomaly Immune accommodation and Immune-Induced effects. The levels of IL-10 illustrated patients with OLP erosion might accompany with disorder of immune system or the immunity was associated with the cause of this disease.