AIB1在乳腺良、恶性病变组织中的表达及临床意义

Expression of nuclear receptor coactivator AIB1 in breast cancer and its clinical significance

目的探讨乳腺良、恶性组织中乳腺癌扩增性抗原1(amplified in breast cancer 1,AIB1)蛋白的表达与临床意义。方法采用免疫组织化学方法检测120例乳腺癌组织、40例良性乳腺病变、20例癌旁正常乳腺组织中AIB1的表达,并探讨该蛋白与乳腺癌患者的肿瘤大小、组织学分级、淋巴结有无转移及基因分型等的关系。结果乳腺癌组织中AIB1过表达(40.0%)显著高于正常乳腺组织(10.0%)和乳腺良性病变组织(15.0%)(P<0.05)。在乳腺癌组织中,组织分级Ⅲ级组的过表达率(62.0%)显著高于Ⅰ级组(10.5%)和Ⅱ级组(29.4%)(P<0.05))。腋淋巴结转移组中的过表达率(53.8%)显著高于淋巴结无转移组(14.3%)(P<0.05)。乳腺癌组织中,AIB1蛋白表达率在ER阳性组(45.2%)、阴性组(27.8%)间的差异无统计学意义(P=0.0741),PR阳性组(42.9%)、阴性组(34.9%)间的差异无统计学意义(P=0.393),而HER2阳性组的AIB1过表达率(51.5%)显著高于阴性组(25.0%)(P<0.05)。乳腺癌组AIB1蛋白的阳性表达率与乳腺癌不同基因分型亚型明显相关(P<0.05)。结论乳腺癌中AIB1过表达与乳腺癌的发生、发展及肿瘤的恶性程度密切相关,AIB1蛋白高表达可能提示临床预后不良。

Objective To investigate the expression of amplified in breast cancer 1（AIB1） protein in breast cancer and its clinical significance.Methods The expressions of AIB1 protein in 120 tissue specimens of breast cancer,20 specimens of normal breast tissue and 40 benign breast lesions were examined by immunohistochemistry.The associations of AIB1 expression with tumor size,histological grades,lymph nodes metastasis and genotype were analyzed.Results The expression rate of AIB1 protein in breast cancer（40.0%） was significantly higher than those in benign lesions（15.0%） and normal breast tissues（10.0%）（P 0.05）.The expression of AIB1 in grade Ⅲ cancer（62.0%） was higher than those in gradeⅠ（10.5%） and gradeⅡ（29.4%） cancer（P 0.05）.The expression rate of AIB1 protein in cases with metastatic lymph nodes（53.8%） was higher than that in those with no metastatic lymph nodes（14.3%）（P 0.05）.The expression rate was higher in patients with HER2（＋）（51.5%） than that in those with HER2（-）（25.0%）（P 0.05）;however,AIB1 expression was not correlated with ER or ER/PR status（both P 0.05） in breast cancer tissue.The over expression rate of AIB1 had correlation with sub-genotype（P 0.05） of breast cancer.Conclusions Upregulation of AIB1 expression is involved in the carcinogenesis and development of breast cancer;it may be used as an indicator for malignant biological behavior and poor prognosis.