蜂蜇伤患者凝血功能和细胞因子水平的变化

Changes of coagulation function and serum cytokines in patients with bee-sting poisoning

将51例蜂蜇伤患者分成轻（22例）、中（20例）、重（9例）度3组，将30名健康者作为正常对照组。检测血IL-8、血管性假血友病因子（vWF）、凝血酶原时间（PT）、部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原（FIB）和D-二聚体水平。轻度组各项指标与正常对照组比较差异无统计学意义（P〉0．05）。中重度中毒组PT、APTF、TT、IL-8、vWF的水平较轻度中毒组明显升高（P〈0．01），重度中毒组的APTT、IL-8、vWF水平又较中度中毒组明显升高（P〈0．01）。

Fifty-one patients with bee-sting poisoning were divided into slight poisoning group （ n = 22）, moderate poisoning group （ n = 20） and severe poisoning group （ n = 9）. And 30 healthy persons were selected as control group. The levels of interleukin-8 （IL-8） , Von Willebrand factor （vWF） , prothrombin time （PT）, activated partial thromboplastin time （APTT）, fibrinogen （FIB）, thrombin time （T-F） and D- dimer were measured. The levels of all parameters in slight poisoning group were no significantly different from with control group （ P 〉 0. 05 ）. The levels of PT, APTT, IL-8 and vWF were significantly higher in moderate and severe poisoning groups than those in the control group （P 〈0. 01 ）. But the levels of APTT, IL-8 and vWF in severe poisoning group were much higher than those in moderate poisoning group （P 〈 0.01 ）. The injury of vascular endothelial cell by IL-8 and vWF caused the change of coagulative function and promoted the progress of inflammation.