老年期抑郁焦虑患者生命质量的研究

Quality of life in elderly patients with anxiety disorders

目的调查老年抑郁症和焦虑障碍共病患者与老年单纯抑郁症患者的生命质量差异。方法根据美国精神障碍诊断手册第四版(DSM-IV)的诊断标准,连续入组108例老年抑郁症患者,其中58例单纯抑郁症(抑郁症组),50例抑郁症和焦虑障碍共病(共病组)。选用健康状况调查问卷(SF-36)、汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)量表对其生命质量进行评定。结果抑郁症组患者的躯体功能(PF)和社会功能(SF)因子分均高于共病组,差异均有统计学意义(t分别=3.95、3.69,P均<0.05)。抑郁症组HAMD和HAMA总分均低于共病组,差异均有统计学意义(t分别=-2.69、-6.16,P均<0.05)。PF与SF呈正相关(r=0.52,P<0.05),与HAMD、HAMA呈负相关(r分别=-0.47、-0.47,P均<0.05);SF与HAMD、HAMA均呈负相关(r分别=-0.45、-0.45,P均<0.05)。结论老年抑郁和焦虑障碍共病患者的生命质量下降,较单纯抑郁患者的抑郁和焦虑症状更重,共病患者的生命质量与其抑郁焦虑症状程度相关。

Objective To investigate the quality of life of geriatric depression combined with anxiety disorders and compare difference with depression without anxiety. Methods There were 108 cases of elderly patients with depression en- rolled in this study according to the American diagnostic manual of mental disorders fourth edition （DSM-IV） diagnostic criteria. There were 58 patients with pure depression as depression group and 50 patients with depression combined with anxiety as comorbidity group. All patients were investigated with Hamilton Depression Rating Scale （HAMD）, Hamilton Anxiety Scale （HAMA） ,and SF-36 Health Survey （SF-36） scale. Results The patients of depression group had higher score of physical function （PF） and social function （SF） than that in the comorbidity group （t=3.95,3.69,P〈0.05）. The to- tal score of HAMD and HAMA in depression group were lower than that in comorbidity group （t=-2.69,-6.16,P〈0.05）. PF was positive related with SF （r=0.52,P〈0.05） but negative related with the HAMD and HAMA （r=-0.47,-0.47,P〈 0.05）. SF was negative related with HAMD and HAMA （r=-0.45,-0.45, P〈0.05）. Conclusions The quality of life of el- derly patients with depression combined with anxiety was worse. They occurred depression and anxiety symptoms more seriously. The quality of life of comorbidity patients was related with depression anxiety symptoms degree.