期刊文献+

小剂量肝素预防过敏性紫癜的肾脏损害76例临床观察 被引量:3

下载PDF
导出
摘要 目的:临床观察小剂量肝素对过敏性紫癜的肾脏损害疗效。方法:将76例过敏性紫癜患儿随机分为两组,治疗组38例,对照组38例,对照组给予抗过敏、改善毛细血管脆性、抑制血小板聚集等常规治疗直至症状消失,治疗组在对照组基础上给予小剂量肝素按5—10U/(kg·次)+10%葡萄糖50.100ml静脉输注,1次/d,疗程7~14d,动态观察6个月尿常规变化。结果:随访6个月时治疗组较对照组肾损害发生率明显降低,差异有统计学意义(P〈0.05)。结论:肝素能降低过敏性紫癜的肾损害的发生,有效预防肾损害的发生。
作者 李勇
机构地区 榆树市医院
出处 《中外医学研究》 2012年第34期28-28,共1页 CHINESE AND FOREIGN MEDICAL RESEARCH
  • 相关文献

参考文献4

二级参考文献29

  • 1周明锦.过敏性紫癜患儿食物过敏原特异性IgG抗体检测[J].郑州大学学报(医学版),2009,44(6):1257-1260. 被引量:16
  • 2胡亚美 江载芳.诸福棠实用儿科学第7版[M].北京:人民卫生出版社,2002.1172.
  • 3Mollica F,Li VS,Carozzo R,et al.Effectiveness of early prednisone treatment in preventing the development of nephropathy in anaphylactoid purpura[J].Eur J Pediatr,1992,151 (2):140-144.
  • 4Saulsbury FT.Corticosteroid therapy does not prevent nephritis in Henoch-Schonlein purpura[J].Pediatr Nephrol,1993,7 (1):69-71.
  • 5Kawasaki Y,Suzuki J,Suzuki H.Efficacy of methylprednisolone and urokinase pulse therapy combined with or without cyclophosphamide in severe Henoch-Schoenlein nephritis:a clinical and histopathological study[J].Nephrol Dial Transplant,2004,19(4):858-864.
  • 6Tanaka H,Suzuki K,Nakahata T,et al.Early treatment with oral immunosuppressants in severe proteinuric purpura nephritis[J].Pediatr Nephrol,2003,18 (4):347-350.
  • 7Shin JL,Park JM,Shin YH,et al.Can azathioprine and steroids alter the progression of severe Henoch-Schonlein nephritis in children?[J].Pediatr Nephrol,2005,20 (8):1087-1092.
  • 8Kano K,Kyo K,Yamada Y,et al.Comparison between pre-and post-treatment clinical and renal biopsies in children receiving low dose cyclosporin-A for 2 years for steroid-dependent nephrotic syndrome[J].Clin Nephrol,1999,52 (1):19-24.
  • 9Hino S,Takemura T,Okada M,et al.Follow-up study of children with nephrotic syndrome treated with a long-term moderate dose of cyclosporin[J].Am J Kidney Dis,1998,31 (6):932-939.
  • 10Shin JI,Park JM,Shin YH,et al.Henoch-Schonlein purpura nephritis with nephrotic-range proteinuria:histological regression possibly associated with cyclosporin A and steroid treatment[J].Scand J Rheumatol,2005,34 (5):392 -395.

共引文献1278

同被引文献47

  • 1代彦林,丁樱,韩姗姗,徐闪闪,胡明格,杜梦珂.丁樱运用藤类药从络脉瘀阻论治紫癜性肾炎经验[J].辽宁中医杂志,2022,49(6):31-33. 被引量:12
  • 2吴力群,丁樱.肾必宁颗粒剂对系膜增生性肾炎系膜细胞凋亡及调控基因Bcl-2、Fas影响[J].中医药学刊,2004,22(9):1607-1608. 被引量:3
  • 3宋纯东,丁樱.肾必宁颗粒对IgA肾病小鼠肾小球系膜细胞凋亡的影响[J].陕西中医,2004,25(10):951-952. 被引量:8
  • 4Egan CA,Taylor TB,Meyer LJ,et al. IgA1 is the major IgA subclass in cutaneous blood vessels in Henoch-Schnolein purpura [J]. Br J Dermatol, 1999,14(5) : 859-862.
  • 5Allen AC,Willis FR,Beattie TJ,et al. Abnormal IgA glyco- sylation in henoch-schonlein purpura restricted to patients with clinical nephritis [J]. Nephrol Dial Transplant, 1998,13 (4) :930-934.
  • 6Novak J, Moldoveanu Z, Renfrow MB, et al. IgA nephropa- thy and Henoch-Schoenlein purpura nephritis:aberrant glycosylation of IgA1 ,formation of IgAl-containing immune complexes, and activation of mesangial cells [J]. Contrib Nep hrol, 2007,157 : 134-138.
  • 7Lau KK,Wyatt RJ,Moldoveanu Z,et aL Serum levels of galac- rose-deficient IgA in children with IgA nephropathy and Henoch-Schonlein purpura [J]. Pediatr Nephrol, 2007,22 (12) :2067-2072.
  • 8Oortwijn BD,Eijgenraam JW,Rastaldi MP,et al. The role of secretary IgA and complement in IgA nephropathy [J]. Semin Nephrol, 2008,28 ( 1 ) : 58-65.
  • 9Endo M,Ohi H,Ohsawa I,et al. Complement activation through the lectin pathway in patients with Henoch-Schon- lein purpura nephritis [J]. Am J Kidney Dis ,2000,35 (3) : 401-407.
  • 10Moura IC ,Arcos-Fajardo M ,Sadaka C ,et al. Glycosylation and size of IgA1 are essential for interaction with mesan- gial transferrin receptor in lgA nephropathy [J]. Am Soc Nep hrol, 2004,15 (3) : 622-634.

引证文献3

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部