期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血清Hs-CRP和MCP-1检测在小儿肺炎支原体感染中的临床价值 被引量：4

下载PDF
导出
摘要 目的:探讨肺炎支原体(MP)患儿血清中超敏C反应蛋白(Hs-CRP)和单核细胞趋化蛋白-1(MCP-1)测定的临床意义。方法:选取63例MP患儿(MP组)治疗前后及60例正常儿童(对照组),采用乳胶免疫比浊法测定Hs-CRP水平和双抗体夹心ELISA法检测MCP-1水平。结果:MP组患儿治疗前的Hs-CRP和MCP-1水平为(7.33±3.67)mg/L和(185.12±51.06)ng/L,显著高于对照组,差异均有统计学意义(P<0.05);MP组患儿治疗后的Hs-CRP和MCP-1值较治疗前均明显降低(P<0.05),但与对照组比较差异无统计学意义(P>0.05)。结论:监测MP患儿的Hs-CRP和MCP-1水平,对于病情及疗效的评估有重要价值。
作者 黄玉玲
机构地区 耒阳市人民医院
出处 《中外医学研究》 2012年第34期47-47,共1页 CHINESE AND FOREIGN MEDICAL RESEARCH
关键词 肺炎支原体 超敏C反应蛋白 单核细胞趋化蛋白-1
分类号 R725.6 [医药卫生—儿科]
  • 相关文献

参考文献3

  • 1胡亚美 江载芳.诸福棠实用儿科学[M].北京：人民卫生出版社,2002.1294.
  • 2DefilippiA, Silvestri M, Tacchella A, et al.Epidemiology and clinicalfeatures of Mycoplasma pneumoniae infection in children[J].Respir Med,2008,102(12) : 1762-1768.
  • 3李文军,李二红,杨宗城.巨噬细胞在炎症消散中的作用[J].免疫学杂志,2000,16(z1):99-101. 被引量：9

二级参考文献11

  • 1[1]MOIRA KW, MEAGHER LC, DERMOT JM, et al.Impairment of function in aging neutrophils is associated with apoptosis [J]. J Immunol, 1993,150 (1):5214-5 134.
  • 2[2]FADOK VA , BRATTON DL , KONOWAL A , et al.Macrophages that have ingested apoptotic cells in vitro inhibit proinflammaory cytokine production through autocrine/paracrine mechanisms involving TGF-beta,PGE2 ,and PAF[J]. J Clin Invest, 1998,101(4) :890-898.
  • 3[3]MEAGHER LC,SAVILL JS,BAKER A,et al. Phagocytosis of apoptotic neutrophils does not induce macrophage release of thromboxane B2 [J]. J leukoc Biol, 1992,52 (3): 269-273.
  • 4[4]SIMONL N, JANET EH, PETERM H. Phagocytosis of senescent neutrophil by human monocyte-derived macrophages and rabbit inflammatory macrophages [J]. J Exp Med,1982,156(8):430-442.
  • 5[5]SAVILL J , HOGGN . REN Y ,etal. Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis[J]. J Clin Invest. 1992.90 (4): 1 513-1 522.
  • 6[6]FADOK VA . SAVILL JS , HASLETT C . et al. Different populations of macrophages use either the vitro-nectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells [J]. J Immunol,1992,149(12):4 029-4 035.
  • 7[7]BELLINGANGJ, CALDWELL H . HOWIE SM, et al.In vivo fate of the inflammatory macrophage during the resolution of inflammation[J]. J Immunol. 1996. 157(6):2 577-2 585.
  • 8[8]GUEIRARDP, DRUILHE A, PRETOLANI M . et al. Role of adenylate cyclase-hemolysin in alveolar macrophage apoptosis during bordetella pertussis infection in vivo[J]. Infection Immunity. 1998,66 (4):1 718-1 725.
  • 9[9]RRYIMA J . KASZNBAZ J . PANLIK J . Alveolar macrophages of childern suffering from recurrent infection of respiratory tract are less efficient in elimi nating apoptotic neutrophils [J]. Pediatr Pulmonol.1999.27(3) :167-173.
  • 10[10]VIGNOLA AM,CHANEZ P.CHIAPPARA G.et al.Evaluation of apoptosis of eosinophils, macrophages and T lymphocytes in mucosal biopsy specimens of patients with asthma and chronic bronchitis[J]. J Allergy Clin Immunol,1999.103(4):563-573.

共引文献494

同被引文献46

  • 1叶棋浓,苏国富,袁艺,黄翠芬.人单核细胞趋化蛋白－1（MCP－1）基因的PCR扩增、克隆及序列分析[J].中华微生物学和免疫学杂志,1994,14(1):29-32. 被引量：6
  • 2胡亚美,江载芳.诸福堂实用儿科学[M].7版.北京:人民卫生出版社,2002:2235-2236.
  • 3Yoshimura T, Robinson EA, Tanaka S, et al.Purification and amino acid analysis of two human glioma-derived mono- eyte chemoattractants[J]. JExp Med, 1989,169(4) : 1 449.
  • 4Yoshimura T, Yuhki N, Moore SK, et al. Human monocy- te chemoattractant protein-1 (MCP-1).Full-length cDNA cloning, expression in mitogen-stimulated blood mononu- clear leukocytes, and sequence similarity to mouse compe- tence gene JE[J].FEBS Lett, 1989,244 (2) : 487.
  • 5Shyy Y J, Li YS, Kolattukudy PE. Structure of human mo- nocyte chemotactic protein gene and its regulation by TPA [J].Biochem Biophys Res Commun, 1990,169 (2) : 346.
  • 6Shyy YJ, Li YS, Kolattukudy PE. Activation of MCP-1 ge- ne expression is mediated through multiple signaling path- ways[J].Biochem Biophys Res Commun , 1993,192 (2) : 693.
  • 7Sica A, Wang JM, Colotta F, et al. Monocyte chemotactic and activating factor gene expression induced in endothe- lial cells by IL-1 and tumor necrosis factor[J]. Jlmmunol, 1990,144(8) :3 034.
  • 8Weber C, Schober A, Zemecke A. Chemokines: key regu- lators of mononuclear cell recruitment in atherosclerotic vascular disease[J]. Arterioscler Thromb Vasc Biol, 2004, 24(11):1 997.
  • 9Siebert H, Sachse A, Kuziel WA, et al. The chemokine re- ceptor CCR2 is involved in macrophage recruitment to the injured peripheral nervous system[J]. J Neuroimmu- nol,2000,110(1/2) : 177.
  • 10Hori M, Nobe H, Horiguchi K, et al. MCP- 1 targeting in- hibits muscularis macrophage recruitment and intestinal smooth muscle dysfunction in colonic inflammation[J]. Am J Physiol Cell Physiol, 2008,294 (2) : C391.

引证文献4

中外医学研究
2012年 第34期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部