我院2007-2011年抗抑郁药物应用情况分析

Analysis of the utilization of antidepressant drug in our hospital during 2007-2011

目的:通过分析我院抗抑郁药使用特点,了解我院抗抑郁药物的应用现状,分析用药特点,预测用药趋势,为促进临床合理用药提供参考。方法:采用回顾性分析方法,对我院2007-2011年抗抑郁药物的销售金额、用药频度(defined daily dose,DDDs)和日均费用(defined daily cost,DDC)等进行统计、分析。结果:新型药物的使用量逐年上升,5年销售金额增长2.2倍,DDDs增长1.89倍;三环类抗抑郁药(TCAs)类药物使用量则逐年下降,5年销售金额下降近40%,DDDs下降近30%。抗抑郁药物的DDC稳中有降,新型药物的DDC是TCAs类药物的10倍。结论:我院抗精神病药物应用基本合理。选择性5-羟色胺再摄取抑制剂(SSRIs)类药物使用的品种最多,使用份额最大;SNRIs类药物呈现快速增长;更多使用国产药物能有效降低抗抑郁药物的DDC。

Objective： To understand the application status of the antidepressants in our hospital, analysis of drug characteristics, forecast of medication trends so as to provide a reference for the promotion of rational clinical use of drugs. Methods： The sales of antidepressant, defined daily dose （ DDDs ） and defined daily cost （ DDC ） in our hospital during 2007-2011 were statistically analyzed by retrospective analysis. Results： The use of new classes of drugs increased year by year and the sales increased by 2.2 times in five years, and DDDs increased by 1.89 times. Tricyclic antidepressants （ TCAs ） drugs has been declining and five- year sales of TCAs and DDDs have dropped by nearly 40% and 30%, respectively. DDC of antidepressant drugs is flat to down while DDC of the new drug increases 10 times than that of the TCAs drugs. Conclusion： The application of antipsychotics in our hospital is reasonable. Selective 5 - serotonin reuptake inhibitors （ SSRIs ） class of drugs were used in the most varieties and largest share and the SNRIs drugs showed a rapid growth. A great use of domestic drug can effectively reduce the DDC of antidepressant drug.