摘要
目的探讨天麻钩藤饮、温胆汤、血府逐瘀汤对自发性高血压大鼠(SHR)心肌组织与血浆醛固酮(AL-DO)和血管紧张素Ⅱ(AngⅡ)的影响。方法将50只16周龄SHR随机分为5组,SHR对照组、卡托普利组、天麻钩藤饮组、温胆汤组和血府逐瘀汤组各10只;另取10只血压正常大鼠作为正常对照组。卡托普利组、天麻钩藤饮组、温胆汤组和血府逐瘀汤组给予相应的药物灌胃,SHR对照组、正常对照组给予等量生理盐水灌胃;均连续用药8周。用药后,采用放免法检测各组血浆及心肌组织的AngⅡ、ALDO含量。结果用药8周后,卡托普利组、天麻钩藤饮组、温胆汤组和血府逐瘀汤组的血浆及心肌组织AngⅡ、ALDO含量均显著降低(P均<0.01);与SHR对照组、正常对照组用药后比较均有统计学差异(P均<0.01)。结论天麻钩藤饮、血府逐瘀汤、温胆汤可明显降低SHR的心肌组织和血浆AngⅡ、ALDO含量,有一定的抗心肌纤维化作用;其机制可能与抑制肾素—血管紧张素—醛固酮系统的激活有关。
Objective To study effect of Tianma gouteng yin, wendan tang, Xuefuzhuyu tang, on the level of aldoste- rone （ALDO） and angiotensin Ⅱ （AngⅡ ） in myocardial tissue and plasma of spontaneously hypertensive rat （SHR）. Methods Fifty 16-weeks-old spontaneous hypertensive rats （SHR） were randomly divided into 5 groups, namely SHR control group, captopril group, Tianmagouteng yin group, Wendantang group and Xuefuzhuyu tang group, each group in- cludes 10 rats, meanwhile, to pick up 10 rats with normal blood pressure as normal control group. Those groups were given corresponding drugs by gastric perfusion, SHR control group and normal control group were given the same amount of sa- line, continuous treated for 8 weeks. Before and after treatment the levels of Ang Ⅱ, ALDO in plasma and myocardium tis- sue were detected by radioimmunoassay. Results After 8 weeks＇ therapy, the results showed that captopfil, Tianmagouteng yin, Wendan tang and Xuefuzhuyu tang can significantly decreased the levels of ALDO and Ang Ⅱ in plasma and myocardium of SHR （ P 〈 0.01 ）. Compared with SHR group and normal control group, there were significant differences （ P 〈 0.01 ）. Conclusion Tianmagouteng yin, Xuefuzhuyu tang and Wendan tang can significantly decrease the levels of AngⅡ, ALDO in myocardial tissue and plasma of SHR, and they also can resist myocardial fibrosis, its mechanism may be related to the inhibition of renin-angiotensin-aldosterone system.
出处
《山东医药》
CAS
2012年第37期11-13,共3页
Shandong Medical Journal
基金
国家自然科学基金资助项目(81072937)
