钛合金表面红细胞吸附特性AFM研究

Study on Adsorptive Properties of Erythrocyte on Titanium Alloy Surface Based on AFM

采用原子力显微镜(AFM)观察吸附在钛合金基底上的红细胞表面形貌,研究红细胞、钛合金与探针之间的微摩擦力,对比分析红细胞表面和钛合金表面同探针之间的微摩擦力-距离关系曲线,及红细胞破损前后的探针与红细胞的微摩擦力-距离关系曲线。结果表明:在外力作用下,红细胞不仅细胞表面形貌受影响,而且其黏性增大,摩擦力增大,影响润滑效果;因红细胞表面柔润粗糙,且探针在活细胞表面所测得的微摩擦力为多种微观力的合力,从而使红细胞表面的摩擦力较大。

The surface topography of erythrocyte adsorbed on the basement of titanium alloy was observed with an atomic force microscope （ AFM）, and the micro-friction between erythrocyte and titanium alloy with probe was studied. The microforce-range curves between erythrocyte and titanium alloy with probe, and the relation curves between erythrocyte and probe before or after erythrocyte damaged were analyzed. The results show that under external force, the surface morphology of red blood ceil is affected, and its viscosity and friction are increased as well, so as to influence the lubrication effect. For the surface of erythrocyte is soft and rough, and the micro friction force measured by the probe on the surface of living cells are composition of micro forces, it results in the larger friction of the red blood cell surface.