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镇咳药——磷酸二甲啡烷 被引量：9

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摘要 磷酸二甲啡烷是一种新型镇咳药,通过直接抑制延髓咳嗽中枢而起镇咳作用,具有毒性低、疗效好、无身体依赖性、不良反应少等特点。该文介绍磷酸二甲啡烷的药效学、药动学、毒理学、临床疗效、上市再评价等进展,为临床应用提供参考。
作者 刘萍 刘薇芝 胡汉昆 颜锵
机构地区 武汉大学中南医院药学部 武汉药谷生物工程有限公司
出处 《医药导报》 CAS 北大核心 2012年第12期1592-1594,共3页 Herald of Medicine
基金 2012年武汉市科技攻关课题(201260523173-4)
关键词 二甲啡烷 镇咳作用
分类号 R974.2 [医药卫生—药品] R969 [医药卫生—药理学]
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参考文献13

  • 1REYNOLDS S M, MACKENZIE A J. The pharmacology of cough [ J ]. Trends In Pharmacological Sci, 2004,25 ( 11 ) : 325-328.
  • 2HISASHI I D A. The nonnarcotic antitussive drug dime- morfan:a review[J].Clin Ther,1997,19(2) :215-231.
  • 3KIM J Y,KIM H C, K1M J,et al. Concise synthesis of dim- emorfan(DF) starting from 3-hydroxymorphinan (3-HM) [J]. Chem Pharm Bull, 2008,56 (7) : 985 -987.
  • 4KAS Y, KITO G, MIYATA T, et al. On the sites of anti- tussive action of d-3-methyl-N-methylmorphinan ( AT-17 ) [ J ]. Arzneim-Forsch Drug Res, 1976,26 ( 3 ) : 361-366.
  • 5KAS Y, KITO G, MIYATA T, et al. Antitussive activity and other related pharmacological properties of d-3-methyl-N- methylmorphinan(AT-17) [ J ]. Arzneim-Forsch Drug Res, 1976,26(3) :353-360.
  • 6IDA T, FUJII N. Pharmacological actions of d-3-methyl-N- methylmorphinan phosphate ( AT-17 ), a new antitussive agent [ J ]. Oyo Yakuri ( Pharmacometrics ) , 1972,6 ( 5 ) : 1207-1231.
  • 7SANO K, ICHIMURA T, TERASAWA K. Absorption dis- tribution, metabolism and excretion of a new antitussive agent, d-3-methyl-N-methylmorphinan phosphate ( AT-17 ) [J]. Clin Rep,1972,6(8) :2110-2121.
  • 8SEKI T. Measurement of plasma level of AT-17, a new an- titussive agent in human subjects[ J]. Rinsho Yakuri, 1972, 3 ( 8 ) :302-304.
  • 9YOSHIDA T, MIKI N, SADO T. Toxicological studies of a antitussive agent, d-3-methyl-N-methylmorphinan phosphate ( AT-17 ) [J]. C/in Rep, 1972,6 ( 3 ) : 2071 - 2090.
  • 10OSHIMA N,ARAKI M, SADO T. Toxicological studies of a new antitussive agent, d-3-methyl-N-methylmorphinan phosphate( AT-17 ) [ J ]. Clin Rep, 1972,6 ( 3 ) : 2091 -2103.

同被引文献38

  • 1薛继雄,周晖.毛细管气相色谱法测定替米沙坦中的有机溶剂残留量[J].中国医院药学杂志,2006,26(3):358-360. 被引量：4
  • 2Kim JY, Kim HC, Kim J, et al. Concise synthesis of dimemorfan ( DF ) starting from 3-hydro-xymorphinan ( 3-HM ) [J]. Chem Pharm Bull (Tokyo) , 2008, 56 ( 7 ) : 985-987.
  • 3王增,余勤,梁茂植,等.HPLC-MS/MS法测定人血浆中二甲啡烷浓度[C]//第十三次临床药理大会论文汇编,2013:309-311.
  • 4Seki T. Measurement of plasma level of AT-17, a new antitussive agent in human subjects [J]. Rinsho Yakuri, 1972: 302-304.
  • 5Gupta S, Banfield C, Affrime M, et al. Desloratadine de- monstrates dose proportionality in healthy adults after single doses [J]. Clin Pharmacokinet, 2002, 41 ( Suppl 1 ) : 1-6.
  • 6Da RL, Squassante L, Milleri S. Dose linearity of lacidipine pharmacokinetics after single and repeated oral doses in healthy volunteers [J]. Clin Pharmacokinet, 2003, 42 ( 1 ) : 99-106.
  • 7Lin CC, Philips L, Xu C, et al. Pharmacokinetics and safety ofviramidine, a prodrug ofribavirin, in healthy volunteers [J]. J Clin Pharmacol, 2004, 44 ( 3 ) : 265-275.
  • 8Chou YC, Chung YT, Liu TY, et al. The oxidative metabo- lism of dimemorfan by human cytochrome P450 enzymes [J]. J Pharm Sci, 2010, 99 (2) : 1063-1077.
  • 9Chou YC, Ueng YF, Chou CY, et al. Dimemorfan N-deme- thylation by mouse liver microsomal cytochrome P450 enzymes [J]. Life Sci, 2005, 77 ( 7 ) : 735-745.
  • 10Tan H, Peng J, Pei Q, et al. Simple and sensitive LC - MS/MS - based assay for the quantification of dimemorfan in human plasma for in a pharmacokinetic study [ EB/OL ]. http:// www. ncbi. nlm. nih. gov, 2014 -09 -29.

引证文献9

二级引证文献13

医药导报
2012年 第12期

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