大剂量他汀强化降脂治疗更多获益及逆转斑块的研究进展

A Review of Recent Advances in Plaque Regression with High-Dose Statin Therapy

近年来多项临床试验证实了他汀强化降脂治疗较之常规降脂治疗具有更显著的临床获益,并且强化降脂治疗能够延缓动脉粥样硬化斑块进展,甚至逆转斑块。现综述近年来有关他汀强化降脂更多获益及逆转斑块的证据,并进一步探讨有关"thelower,the better"的结论的临床应用及他汀逆转斑块的相关机制。

Many studies have investigated the efficacy and safety of statin therapy with more aggressive lipid lowering. These studies have confirmed that there are clinical benefits and plaque regression. This review is a brief overview of recent, large-scale, randomized, pla- cebo and active controlled trials of statin therapy with more aggressive lipid lowering, a discussion of ＂the lower, the better＂ and its usable condition, and the regression of coronary atherosclerosis.