法罗培南钠的波谱学数据与结构确证

Spectral Analysis and Structural Elucidation of Faropenem Sodium

法罗培南钠是一种新型的口服青霉烯类抗生素,对法罗培南钠的紫外吸收光谱(UV)、红外吸收光谱(IR)、质谱(MS)、核磁共振氢谱(1 H NMR)、氢-氢相关谱(1 H-1 H CO-SY)、核磁共振碳谱(13 C NMR)、DEPT谱、异核单量子相关谱(HSQC)、异核多键相关谱(HMBC)进行了解析,对其所有的NMR谱信号进行了归属;讨论了红外光谱特征吸收峰所对应的官能团的振动形式,确证了法罗培南钠的结构.

Faropenem sodium is a new and orally administered β-lactam antibiotic. The spectral data of faropenem sodium were reported, including UV, IR, MS, EA, TGA and NMR data. The NMR data included one dimensional 1H and laC NMR spectra and two-dimensional spectra including ^1H-^1H COSY, HSQC and HMBC. The NMR and IR signals were assigned. The molecular structure of faropenem sodium was determined.