急性缺血性脑卒中患者尿酸和高敏C反应蛋白检测的临床意义

Clinical Significance of Uric Acid and High-Sensitivity C-Reactive Protein Determination in Patients with Acute Ischemic Stroke

目的探讨急性缺血性脑卒中(AIS)患者血清中尿酸(UA)和高敏C反应蛋白(hs-CRP)水平变化的临床意义。方法 AIS患者223例,其中大面积脑梗死组49例,非大面积脑梗死组174例,对照组240例,分别测定其UA和hs-CRP水平,并进行比较分析。结果 AIS患者血清UA和hs-CRP水平较对照组均升高(P<0.05);大面积脑梗死组UA和hs-CRP水平较非大面积脑梗死组和对照组明显升高(P<0.05);非大面积脑梗死组较对照组UA(P>0.05)和hs-CRP(P<0.05)水平有所升高。结论血清UA和hs-CRP与AIS的发生有关,且hs-CRP水平能反映脑梗死的病变程度。

Objective To explore the clinical significance of serum uric acid （UA） and high-sensitivity C-reactive protein（hs-CRP） in patients with acute ischemic stroke（AIS）. Methods Total 223 cases of AIS were divided into 49 cases with large cerebral infarction and 174 cases with non-large cerebral infarction. 240 cases were veeruited as the normal control group. The UA and hs-CRP level were detected and the results were analyzed statistically. Results The UA and hs-CRP in AIS group were higher than those in the control group and the differences had statistical significance（ P 〈 0.05 ）. Large cerebral infarction group was compared with non-large cerebral infarction group and normal control group, and the differences had statistical significance （ P 〈 0.05 ）. Non-large cerebral infarction group was compared with normal control group, and the difference of UA had no statistical significance （P 〉 O. 05 ）. The difference of hs-CRP had statistical signifi cance （ P 〈 0.05 ）. Conclusion The UA and hs-CRP level are related with AIS and the hs-CRP level can reflect the de gree of cerebral infarction.