期刊文献+

神经病靶标酯酶相关性运动神经元疾病 被引量:1

下载PDF
导出
摘要 神经病靶标酯酶(NTE)作为有机磷酸酯的靶标是在有机磷酸酯诱导的迟发性神经毒性(OPIDN)中被发现的,然而近年发现NTE基因的突变与一种运动神经元疾病(MND)的发生相关。本文就NTE、NTE突变引起的MND以及NTE突变引起MND的机制等方面进行了综述。
出处 《中南医学科学杂志》 CAS 2012年第6期624-626,634,共4页 Medical Science Journal of Central South China
基金 重庆市自然科学基金项目(CSTC 2010BB5410)
  • 相关文献

参考文献17

  • 1Jokanovi M, Kosanovi M, Brki D, et al. Organophosphate induced delayed polyneuropathy in man:an overview [ J ]. Clin Neurol Neurosurg,2011,113 (1) :7-10.
  • 2Abdollahi M, Karami-Mohajeri S. A comprehensive review on experimental and clinical findings in intermediate syn- drome caused by organophosphate poisoning [ J ]. Toxicol Appl Pharmaco1,2012,258 ( 3 ) :309-314.
  • 3Chang PA, Wu YJ. Neuropathy target esterase:an essen- tial enzyme for neural development and axoual mainte- nance[Jl. Int J Biochem Cell Biol, 2010,42 (5): 573 -575.
  • 4Giynn P. Neuropathy target esterase and phospholipid deacylation [ J ]. Biochim Biophys Acta, 2005,1736 ( 2 ) : 87 -93.
  • 5Rainier S, Bui M, Mark E, et al. Neuropathy target ester- ase gene mutations cause motor neuron disease [ J ]. Am J Hum Genet ,2008,82 ( 3 ) :780-785.
  • 6Rainier S, Albers JW, Dyck PJ, et al. Motor neuron dis- ease due to neuropathy target esterase gene mutation: clinical features of the index families [ J ]. Muscle Nerve, 2011,43(1) :19-25.
  • 7Hein ND, Stuckey JA, Rainier SR, et al. Constructs of hu- man neuropathy target esterase catalytic domain contai- ning mutations related to motor neuron disease have al- tered enzymatic properties [ J ]. Toxicol Lctt, 2010, 196 (2) :67-73.
  • 8Hein ND, Rainier SR, Richardson RJ, et al. Motor neuron disease due to neuropathy target esterase mutation:enzyme analysis of fibroblasts from human subjects yields insights into pathogenesis [ J ]. Toxicol Lett,2010,199 ( 1 ) : 1-5.
  • 9Chang PA, Wu YJ. Motor neuron diseases and neurotoxic substances : a possible link [ J 1- Chem Biol Interact, 2009, 180(2) :12%130.
  • 10Read DJ,Li Y, Chao MV,et a|. Neuropathy target ester- ase is required for adult vertebrate axon maintenance [J]. J Neurosci,2009,29(37) :11594-11600.

同被引文献6

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部