布地奈德雾化吸入预防毛细支气管炎患儿喘息的近期及远期疗效观察

Recent and Long-Term Effects of Budesonide Inhalation in the Preventing Recurrent Wheezing in Children with Bronchiolitis

目的:观察雾化吸入布地奈德混悬液预防毛细支气管炎后再次喘息发作的临床疗效。方法:选择2009年1月至2010年1月我院住院的毛细支气管炎患儿114例,随机分为3组:A组38例仅给予综合对症治疗,未给予吸入布地奈德混悬液;B组36例在综合对症治疗基础上吸入布地奈德混悬液治疗1周;C组40例在综合对症治疗基础上吸入布地奈德混悬液治疗3月。观察患儿急性期临床症状、体征改善情况;3个月后随访观察1年,观察患儿再发喘息的情况。结果:B、C组临床症状、体征改善时间均短于A组(P均<0.01);B、C组观察期内再发喘息例数均明显少于A组(P均<0.01)。结论:毛细支气管炎患儿在急性期和急性期后雾化吸入布地奈德混悬液,可缩短病程、改善症状,减少远期再次喘息发作。

Objective： To observe the therapeutic efficacy of inhalation of budesonide in the preventing recurrent wheezing after acute bronchiolitis.Methods： A total of 114 children with bronchiolitis admitted to this hospital from 2009 January to 2010 January were randomly divided into three groups： group A（n=38） received routine comprehensive treatment,group B（n=36） inhaled budesonide for one week on the basis of comprehensive symptomatic treatment and group C（n=40） inhaled budesonide for three months on the basis of comprehensive symptomatic treatment.The improvements of clinical symptoms and signs in acute phase in the three groups were observed.After three months,these bronchiolitis children had been followed up for one year without special medication in order to observe the recurrent wheezing.Results： The improvement times of clinical symptoms and signs in group B and group C were statistically significantly shorter than those in group A（P〈0.01）.During the observation period,the numbers of cases of recurrent wheezing in group B and group C were obviously fewer than those in group A（P〈0.01）.Conclusions： Inhaled budesonide treatment could shorten the course of bronchiolitis in the acute phase and after acute phase,improve clinical symptoms and signs and reduce the long-term onset of recurrent wheezing.