急性呼吸道感染住院患儿鼻咽部病毒检测分析

Viral etiology of hospitalized children with acute respiratory tract infection

目的:调查盐城地区急性呼吸道感染(ARI)住院患儿的病毒病原学情况,为本地区儿童ARI防治提供依据。方法:收集2011年6月至2012年7月ARI患儿的鼻咽分泌物标本1 582份,采用直接免疫荧光法检测呼吸道合胞病毒(RSV)、流感病毒A(IVA)、流感病毒B(IVB)、副流感病毒1-3(PIV 1-3)以及腺病毒7种病毒。结果:1 582例标本中有426例检出病毒(26.9%),其中RSV检出率最高,为289例(18.3%),其次是腺病毒,为46例(2.9%);病毒的总检出率在年龄及季节分布上有统计学差异,以6个月～1岁年龄组检出率最高,冬春季发病率较高。结论:RSV及腺病毒是盐城地区ARI住院患儿病毒感染的主要病原体,其检出率与年龄及季节分布有明显相关性。

Objective：To investigate the viral etiology of acute respiratory tract infection（ARI） of hospitalized children in Yancheng of Jiangsu province so as to provide experimental evidence for children with ARI in the area.Methods：The nasopharyngeal aspirate samples from June 2011 to July 2012 were obtained from 1 582 hospitalized children with ARI.Respiratory syncytial virus（RSV）,influenza A（IVA）,influenza virus B（IVB）,parainfluenza virus 1-3（PIV1-3） and adenovirus were detected by direct immunofluorescence.Results：Four hundred and twenty six case were shown to be infected by respiratory virus in 1582 pediatrics patients and the positive rate was 26.9%.RSV were most frequent（18.3%）,followed by adenovirus（2.9%）.The overall detection rate of the virus showed significant differences in different age group and seasonal distribution.The highest detection rate of respiratory virus was among children aged 6 month to 1 year and the incidence was higher in winter and spring than in other seasons.Conclusion：RSV and adenovirus was the predominant pathogens of ARI of hospitalized children in Yancheng and the positive rate was significantly associated with age and seasonal distribution.