老年缺血性脑白质疏松症与微量白蛋白尿的相关性研究

Relationship Between lschemic Leukoaraiosis and Microaibuminuria in Elderly Patients

【目的】探讨老年缺血性脑白质疏松症（LA）与微量白蛋白尿（MAU）的关系。【方法】选择105名男性患者，经头MRI检测将患者分为无或轻度LA组68例，中重度LA组37例。测定患者24h尿蛋白排泄率。同时记录患者疾病史，检测胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LD-C）、高密度脂蛋白胆固醇（HDL-C）、尿酸（UA）、同型半胱氨酸（Hcy）水平。【结果】无或轻度LA组MAU阳性率为16．1％，中或重度LA组MAU阳性率为37．8％，两组比较，差异有统计学意义（P〈0．01）。多因素logistic回归分析显示：年龄、高血压、微量白蛋白尿、高同型半胱氨酸血症与脑白质疏松严重程度相关（P〈0．05）。【结论】微量白蛋白尿是脑白质疏松的独立危险因素，可作为脑白质疏松严重程度的预测指标。

[Objective]To explore the relationship between microalbuminuria（MAU） and ischemic leuko- araiosis（LA） in elderly patients. [Methods] According to cerebral MRI, 105 male patients were divided into no or mild LA group（ n =68） and moderate to severe LA group（ n = 37）. The 24-hour urine albumin excre- tion rate of patients was measured. Disease history was recorded. Total cholesterol（TC）, triglyceride（TG）, low density lipoprotein（LDL-C）, high density lipoprotein（HDL-C）, uric acid（UA） and homocysteine（Hcy） were measured. [Results] The positive rate of MAU in no or mild LA group was 16.1 %. The posit）re rate of MAU in moderate to severe LA group was 37.8%. There was significant difference in the positive rate of MAU between two groups（ P 〈0.01）. Multivariate logistic regression analysis showed that age, hyperten- sion, MAU and Hcy were associated with the severity of leukoaraiosis. [Conclusion] MAU is an independent risk factor for leukoaraiosis. MAU can be used as the predictive indicator of the severity of leukoaraiosis.