放射治疗非小细胞肺癌脑转移40例临床疗效分析

Clinical Analysis of the efficacy of Radiation Therapy in Non Small Cell lung Cancer with Brain Metastasis

目的总结放疗治疗非小细胞肺癌脑转移患者的临床疗效。方法回顾性分析40例非小细胞肺癌脑转移患者的临床特征,放疗后生存率及预后因素。结果 40例患者1年生存率为47.7%,2年生存率为17.9%,3年生存率为3%;中位生存期为10个月。腺癌组生存时间优于鳞癌组(P<0.05),孤立脑转移组生存时间优于多个脑转移组(P<0.001)。年龄>60岁组与<60岁组生存期比较差异无统计学意义(P>0.05)。结论放射治疗是非小细胞肺癌脑转移患者主要的治疗手段,亚组分析显示病理类型为腺癌及孤立性脑转移者可从放射治疗中获得更好的生存率。

Objective To analyze the efficacy of radiotherapy in non small cell lung cancer with brain metastasis. Methods A retrospective analysis from January 2006 to January 2009 were admitted, 40 cases of non small cell lung cancer with brain metastasis were analyzed with clinical features, survival and prognostic factors after radiation therapy. Results 1 year survival of the whole group of patients was 47.7 %, and 2 years survival rate was 17.9%, 3 year survival rate of 3 % ; median survival time of 10 months. Adenoearcinoma group survival time superior to squamous cell carcinoma group （P=0. 012）, isolated brain metastasis survival time superior to multiple brain metastasis （P=0. 001）. More than 60 years of age group and less than 60 years old group survival difference was not statistically significant （P〉0. 033）. Conclusion Radiotherapy is important in treatment of non small cell lung cancer patients with brain metastases, and subgroup analysis showed that patients with the pathological types of adenocarcinoma and solitary isolated brain metastasis obtained survival benefit from radiation therapy.