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Notch1信号通路与白藜芦醇抗急性T淋巴细胞白血病作用机制研究进展 被引量：1

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摘要 急性T淋巴细胞白血病(T-ALL)是一类预后不良的恶性淋巴细胞增殖性疾病。T-ALL的发生与Notch1及其介导的信号通路密切相关。Hes-1基因是Notch1的靶基因,被激活后通过PTEN/PI3K/Akt/mTOR信号通路抑制抑癌基因p53表达阻止细胞凋亡,诱导T-ALL发生。白藜芦醇(Res)是一种具有化学防癌作用的多酚类植物抗生素。Res对T-ALL Molt-4细胞具有抑制增殖、诱导凋亡的作用。但Res是否通过Notch1通路发挥作用及其机制尚不十分清楚。本文就Notch1信号通路与T-ALL的发生、治疗以及Notch1信号通路与白藜芦醇抗T-ALL作用机制的研究现状作一综述。
作者 李永军 史敏 秦永亮
机构地区 河北医科大学第二医院检验科
出处 《临床检验杂志》 CAS CSCD 北大核心 2012年第10期799-802,共4页 Chinese Journal of Clinical Laboratory Science
关键词 Notch1信号通路 急性T淋巴细胞白血病 白藜芦醇
分类号 R733.71 [医药卫生—肿瘤]
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参考文献30

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共引文献39

同被引文献23

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临床检验杂志
2012年 第10期

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