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Girdin蛋白在细胞信号通路中的作用 被引量：1

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摘要 Girdin是1个多结构域的信号分子，它能与磷酸肌醇3激酶（P13K）、Gα和蛋白激酶B（Akt）等结合并发生相互作用，在细胞信号转导过程中起着桥梁和纽带的作用。研究结果显示Girdin在促进细胞迁移及血管生成等方面具有重要作用，细胞迁移是胚胎发育、炎症、血管发生和肿瘤发展等病理生理过程的关键环节。研究结果表明Girdin及相关信号通路在多种病理生理过程中发挥重要作用，包括伤口愈合、巨噬细胞趋化性、肿瘤细胞迁移、在血管形成期间内皮细胞迁移等。
作者 王丽 李智慧 谷峰 马勇杰
机构地区 天津医科大学附属肿瘤医院研究所肿瘤细胞生物学室 乳腺病理研究室乳腺癌防治教育部重点实验室天津市"肿瘤防治"重点实验室
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2012年第12期2622-2623,共2页 Chinese Journal of Experimental Surgery
关键词 细胞信号通路 n蛋白 肿瘤细胞迁移 病理生理过程 磷酸肌醇3激酶 细胞信号转导 内皮细胞迁移 信号分子
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献18

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二级参考文献22

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共引文献10

同被引文献8

  • 1Yamazaki D, Kurisu S ,Takcnawa T. Regulation of cancer cell motility through actin reorganization[ J]. Cancer Sci ,2005,96 (7) :379-386.
  • 2Garcia-Marcos M, Jung BH, Ear J, et al. Expression of GIV/Girdin, a Metastasis-related protein, predicts patient survival in colon cancer [J]. FASEB J,2011,25(2) :590-599.
  • 3Liu C, Zhang Y, Xu H, et al. Girdin protein: a new potential distant metastasis predictor of breast cancer [ J ]. Med Oncol, 2012,29 ( 3 ) : 1554-1560.
  • 4Jiang P, Enomoto A, Jijiwa M, et al. An actin-binding protein Girdin regulates the motility of breast cancer cells[ J]. Cancer Res,2008,68 (5) :1310-1318.
  • 5Jun BY,Kim SW,Jung CK,et al. Expression of girdin in human eolor- eetal cancer and its association with tumor progression [ J ]. Dis Colon Rectum,2013,56( 1 ) :51-57.
  • 6Liu C, Xue H, Lu Y, et al. Stem cell gene Girdin :a potential early liv- er metastasis predictoor of eolorectal cancer[ J]. Mol Biol Rep ,2012, 39(9) :8717-8722.
  • 7王静,丁婷,刘晓丽,李文良,谷峰,马勇杰.Girdin蛋白调控恶性胶质瘤细胞凋亡的研究[J].中华实验外科杂志,2011,28(5):733-736. 被引量：9
  • 8丁耘峰,平金良,周余人,马志红,王晓红.Girdin在乳腺浸润性导管癌中的表达及与E-cadherin、MVD的关系[J].江苏医药,2014,40(3):316-319. 被引量：6

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中华实验外科杂志
2012年 第12期

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