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瘦素和瘦素受体在肺癌组织中的表达 被引量：1

Expressions of Leptin and Leptin Receptor in Lung Cancer
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摘要 目的探讨瘦素及其受体在肺癌发生、发展中的作用。方法采用免疫组化S-P法检测68例肺癌组织、相应癌旁组织和正常肺组织中瘦素及其受体的表达。结果瘦素及其受体在肺癌组织中的表达率分别为72.06%(49/68)、64.71%(44/68),相应癌旁组织分别为42.65%(29/68)、33.83%(23/68),正常肺组织分别为26.47%(18/68)、29.41%(20/68)。瘦素及其受体在肺癌组织的表达高于相应癌旁组织及正常肺组织(P<0.05)。在肺癌组织中瘦素与瘦素受体的表达呈正相关关系(r=0.754,P<0.01)。结论瘦素及其受体的表达在肺癌的发生、发展中起一定的促进作用。 Objective To investigate the role of leptin and leptin receptor in the carcinogensis and develop- ment of lung cancer. Methods The expressions of leptin and leptin receptor was detected in 68 cases of lung cancer tissues,homologous paraneoplastic tissues and homologous normal lung tissues. Results The expression rates of leptin and leptin receptor in the lung cancer tissues were 72.06% （49/68） and 64.71% （44/68） ,re- spectively; were 42.65% （29/68） and 33.83% （23/68） in the homologous paraneoplastic tissues, respective- ly ; and were 26.47% （ 18/68 ） and 29.41% （20/68） in the homologous normal lung tissues, respectively. The expression rates of leptin and leptin receptor in lung cancer tissues was significantly higher than those of the ho- mologous paraneoplastic tissues and the homologous normal lung tissues （ P 〈 0.05 ）. The expression of leptin was positively related to leptin receptor in lung cancer tissues. Conclusion Leptin and leptin receptor play the important roles in the carcinogensis and development of lung cancer.
作者 刘毅 吴风雷 胡楠 杨成喜
机构地区 连云港市第一人民医院病理科
出处 《肿瘤基础与临床》 2012年第6期483-485,共3页 journal of basic and clinical oncology
关键词 肺癌 瘦素 瘦素受体 lung cancer leptin leptin receptor
分类号 R734.2 [医药卫生—肿瘤]
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参考文献12

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同被引文献18

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  • 10梁朝晖,张维彬,胡少为,李伟平.食管癌组织中表皮生长因子受体和上皮钙粘附素的表达及其临床意义[J].实用医学杂志,2009,25(8):1249-1251. 被引量：15

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肿瘤基础与临床
2012年 第6期

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