局部晚期宫颈癌53例新辅助化疗的疗效观察

Clinical Observation of Neoadjuvant Chemotherapy in the Treatment of Patients with Locally Advanced Cervical Cancer

目的探讨紫杉醇联合卡铂方案的新辅助化疗(NACT)对局部晚期宫颈癌(LACC)的近期疗效和毒副反应。方法 NACT组53例LACC患者术前行紫杉醇联合卡铂方案的NACT,化疗结束3周后行子宫根治性手术;而对照组47例LACC患者仅常规术前准备后行子宫根治性手术。观察NACT组的化疗疗效和毒副反应以及2组的手术情况。结果 NACT组化疗有效率为83.02%,且毒副反应较轻。NACT组的术后脉管瘤栓阳性率、切缘阳性率、淋巴结转移率、并发症发生率及复发率均低于对照组,差异均有统计学意义(P均<0.05)。结论紫杉醇联合卡铂方案的NACT对LACC近期疗效好,有利于手术的顺利进行,且手术预后也较好。

Objective To investigate the short term efficacy and toxicities of neoadjuvant chemotherapy （NACT） with paclitaxel combined with carboplatin in the treatment of patients with locally advanced cervical cancer （LACC）. Methods The 53 patients with LACC of the NACT group received the NACT with paclitaxel combined with carboplatin, and received the radical surgery in 3 weeks after NACT ; the 47 patients of the control group direct- ly received the radical surgery. The efficacy and toxicities of NACT and the surgery conditions of the two groups were observed respectively. Results The chemotherapy effective rate was 83.02% of the NACT group, the toxicities of chemotherapy were mild. The vascular invasion positive rate, surgical margin positive rate, lymph node metastasis rate, complication rate and recurrence rate of the NACT group were lower than those of the control group （P 〈 0.05 ）. Conclusion NACT with paclitaxcl combined with carboplatin has the good short term efficacy for LACC, and is conducive to the smooth progress of surgery, and its surgical outcomes are better than the radical surgery a- lone.