青年男性寻常痤疮患者膳食生糖负荷水平与皮损严重程度间的相关性研究

Association between dietary glycemic load and severity of skin lesions in young adult males with acne vulgaris

目的通过调查青年男性寻常痤疮患者的膳食生糖负荷水平（GL），评估其与寻常痤疮皮损严重程度间的相关性，为寻常痤疮综合治疗提供参考。方法使用痤疮综合分级系统（GAGS）评价患者皮损严重程度。使用食物频率问卷及24h膳食回顾问卷评估GL水平。方差分析及f检验分析GL及BMI在各组间的差异，并对BMI和GL的影响因素进行Logistic回归分析。结果99例19～24岁男性寻常痤疮患者参与本次研究，Logistic回归结果显示，GL是体质指数（BMI）的影响因素，GL越高BMI越容易超标（回归系数B：1．119，P〈0．05，OR：3．062，95％置信区间：1．044～8．986）。未发现GL的影响因素。病程〉6个月组GL显著高于≤6个月组（t=2．947，P〈0．01）；两组间BMI差异无统计学意义（f=0．798，P〉0．05）。GL在不同GAGS组间差异有统计学意义（F=76．296，P〈0．01），≥31分组高于19。30分组（P〈0．01）和1～18分组（P〈0．01），19—30分组高于1～18分组（P〈0．01）；各组间BMI差异无统计学意义（F=3．142，P〉0．05）。结论GL水平与青年男性寻常痤疮患者皮损严重程度及病程正相关。

Objective To assess dietary glycemic load （GL） in young adult males with acne vulgaris and to evaluate its association with severity of skin lesions, in hope to provide evidences for comprehensive treatment of aene vulgaris. Methods The Global Acne Grading System （GAGS） was used to evaluate the severity of ache, and food frequency questionnaire （FFQ） and 24-hour dietary recall （24-HDR） to assess GL. Differences in GL and body mass index （BMI） were assessed by t test and analysis of variance, and Logistic regression analysis was conducted to analyze the factors influencing BMI and GL. Results This study included 99 young adult males with ache vulgaris who were 19-24 years old. Logistic regression analysis revealed that GL was the risk factor of BMI, and higher GL was always associated with increased BMI （13 = 1.119, P 〈 0.05, OR = 3.062, 95% confidence intervals： 1.044-8.986）. No factors were found to have influences on GL. The patients with a disease duration of 〉 6 months showed a higher GL （t = 2.947, P 〈 0.01）, but similar BMI （t = 0.798, P 〉 0.05） compared with those with a disease duration of 〈6 months. Significant differences were observed in GL （F = 76.296, P 〈 0.01 ）, but not in BMI （F = 3.142, P 〉 0.05）, among the three groups of patients with different GAGS score. GL was higher in patients with GAGS score of 〉39 than those with GAGS score of 1-18 （P 〈 0.01 ） and GAGS score of 19-30 （P 〈 0.01 ）, and higher in patients with GAGS score of 19-30 than in those with GAGS score of 1-18 （P 〈 0.01 ）. Conclusion GL is positively correlated with the severity of lesions and disease duration in young adult males with acne vulgaris.