摘要
目的:探讨ω-3多不饱和脂肪酸(ω-3PUFA)治疗急性肺损伤(ALI)病人的临床效果及其应用价值。方法:计算机检索PubMed、EMBASE、SCI、Cochrane Library、中国生物医学文献数据库、中文科技期刊全文数据库、中国期刊全文数据库和中华医学会数字化期刊,并辅助手工检索,收集采用ω-3PUFA治疗ALI的随机对照试验(RCT),检索至2012年10月截止。采用Jadad评分评价纳入研究质量,用RevMan 5.1软件进行Meta分析。结果:共纳入6个RCT,各试验间资料均有可比性。经Meta分析结果显示,试验组(ω-3PUFA治疗组)与对照组(常规治疗组)在ALI病人的动脉氧分压(PaO2)、氧合指数(PaO2/FiO2)、入住ICU时间(LOS)和总蛋白(TP)等方面均有显著性差异,而撤离呼吸机时间(LOV)和不良反应则无显著性差异。结论:ω-3PUFA可有效地改善ALI病人的呼吸功能,促进病人呼吸功能的恢复和预后。但其长期疗效和不良反应仍需开展更多高质量的研究。
Objective： To evaluate the impact of omega-3 fatty acids intervention on clinical outcomes in acute lung injury patients.Methods： Literatures relating to the evaluation of the omega-3 fatty acids in acute lung injury patients were searched in databases including PubMed,EMBASE,Cochrane Library,Web of Science,Chinese Biomedical Databases,China National Knowledge Infrastructure,and Wanfang Database etc.All the eligible studies were randomized controlled trials and their results were published up to October 2012.The quality of the included studies was evaluated by Jadad evaluation standard.The data were analyzed with RevMan 5.1 from the Cochrane Collaboration.Results： Totally 6 randomized controlled trials entered final meta analysis study and the baseline data of each trial were comparable.The results showed a significant effectiveness in the PaO2,PaO2/FiO2,Total Protein,LOS.However,the length of LOV stay and adverse effects showed no significant difference between two group.Conclusion： Omega-3 fatty acids interventions can benefit patients by reducing the morbidity of postoperative infectious complications and shortening the length of hospital stay.
出处
《肠外与肠内营养》
CAS
北大核心
2012年第6期324-328,共5页
Parenteral & Enteral Nutrition
基金
兰州大学创新创业行动计划资助(LZDX65)
