摘要
端粒是维持染色体稳定性和完整性的重要结构。端粒长度的变化可导致染色体不稳定性增加,从而诱导肿瘤发生,是一种潜在的肿瘤发生风险指标。然而肿瘤组织取材存在获取时机晚、创伤性大等问题,而肿瘤替代组织易于获取且创伤性小,因此检测肿瘤替代组织端粒长度有望成为肿瘤早期筛查的新手段。近年来关于肿瘤替代组织端粒长度与消化系统肿瘤发生风险关系的研究日益增多,但研究结果不尽一致。本文就此作一综述。
Telomere plays a critical role in chromosome stability and integrity. The variation of telomere length may lead to tumorigenesis by increasing chromosome instability. Therefore, telomere length is a potential marker of cancer risk. Compared to tumor tissue, surrogate tissues are easy to collect at an earlier time with less invasion, so measuring telomere length of surrogate tissues has the potential to be a screening tool for early detection of cancer. There has been an increasing number of studies on the relation of surrogate tissue telomere length with risk of digestive system cancer in recent years, however, the results were in discrepancy. This article reviewed the studies on this issue.
出处
《胃肠病学》
2012年第11期696-698,共3页
Chinese Journal of Gastroenterology
关键词
端粒
肿瘤
消化系统
Telomere
Neoplasms
Digestive System