阿利苯多对大鼠围产期毒性的

The toxic effects of Alibendol during perinatal period in rats

目的:观察阿利苯多对大鼠妊娠晚期、分娩期、哺乳期及胚胎和胎仔出生后生长发育、学习能力以及生殖能力的影响。方法:从大鼠妊娠第15天至哺乳第21天,分别连续灌胃给予50、100和200mg/(kg·d)剂量的阿利苯多,同时设0.5%羧甲基纤维素钠为溶剂对照组,观察各组大鼠和胎仔的生长、发育、生殖能力等指标。结果:F0代未见明显毒性反应。F1代,在出生第1天、第4天及雄性性成熟时,低剂量组仔鼠体质量与溶剂对照组比较显著增加(P<0.05);低剂量组张耳达标时间及中剂量组的痛阈时间与溶剂对照组比较差异显著(P<0.05),但均无量效关系;其余各指标及学习和运动能力与溶剂对照组比较差异无统计学意义(P>0.05),另F1代的同笼交配率、妊娠率及胚胎发育全过程未见明显的生殖、发育等毒性变化。结论:在本实验条件下,阿利苯多对妊娠/哺乳的雌性动物以及胚胎和子代发育、行为及生殖无明显毒性。

OBJECTIVE：To identify the toxic effects of Alibendol on the maternal rat in late trimester of pregnancy,the growth and development,and the abilities of learning and reproduction of the offsprings. METHODS：SD pregnant rats were given Alibendol orally from gestational day 15 to weaning day 21. The experimental groups received 50,100 and 200 mg/（kg·d） of Alibendol.The growth,development and reproductive capacity of pregnant rats and offsprings were recorded. RESULTS：There were no obviouse toxic effects on F0 rats.For the body weight of fetal rats（F1）,there was a significant increase in low-dose group compared with control group at birth, day 4 after birth and mature male （P0.05）. However,a significant difference of fetal rats in ear path opening in low-dose group and pain threshold time in meddle-dose group compared with control group （P0.05） were observed too. But there was no dose-effect relationship. There were no differences between treated groups and control group in other indexes. CONCLUSION：Among the dose range used,Alibendol was safe to reproductive capability of female rats and growth of fetal rats.