期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

caveolin-1基因与肿瘤发生相关性的研究进展 被引量：1

下载PDF
导出
摘要 caveolin-1(cav-1)基因目前被认为是一种抑癌候选基因。它编码的胞膜窖标志性蛋白Caveolin-1(Cav-1)具有调控细胞的分化、增殖、迁移和凋亡等功能,在肿瘤发生和形成过程中起着非常重要的作用。cav-1基因在多种肿瘤细胞中表达,不仅表达模式存在明显差异,而且具有致癌和抑癌双重作用。本文着眼于基因水平,从cav-1基因编码的两个亚型、基因突变以及启动子甲基化等方面综述Cav-1在肿瘤发生和发展过程中的作用和机制,为预防和监测肿瘤的发生以及药物研发提供科学依据。
作者 莫赛军 张淑伟 杨胜利
机构地区 郑州大学基础医学院食管癌教研室
出处 《癌变．畸变．突变》 CAS CSCD 2012年第6期477-479,共3页 Carcinogenesis,Teratogenesis & Mutagenesis
基金 国家自然科学青年基金(81101686) 河南省教育厅重点项目(12A310008)
关键词 肿瘤 CAVEOLIN-1基因 基因突变 甲基化
分类号 R735.1 [医药卫生—肿瘤]
  • 相关文献

参考文献19

  • 1Goetz JG, Lajoie P, Wiseman SM, et al. Caveolin-1 in tumor progression: the good, the bad and the ugly[J]. Cancer Metastasis Rev, 2008, 27(4): 715-735.
  • 2Burgermeister E, Liscovitch M, Rficken C, et al. Caveats of caveolin- 1 in cancer progression[J]. Cancer Lett, 2008, 268 (2): 187-201.
  • 3王璐,莫赛军,厉洁,李青,崔宗斌.斑马鱼窖蛋白-1基因cDNA克隆及功能初步研究[J].水生生物学报,2010,34(6):1083-1090. 被引量：5
  • 4Schlegel A, Aryan P, Lisanti MP. Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the endoplasmic reticulum[J]. J Biol Chem, 2001, 276 (6): 4398-4408.
  • 5Sunaga N, Miyajima K, Suzuki M, et al. Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer[J]. Cancer Res, 2004, 64 (12): 4277-4285.
  • 6Joshi B, Strugnell SS, Goetz JG, et al. Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion[J]. Cancer Res, 2008, 68(20): 8210-8220.
  • 7Williams TM, Lisanti MP. Caveolin-1 in oncogenic transformation, cancer, and metastasis[J]. Am J Physiol Cell Physiol, 2005, 288 (3): 494-506.
  • 8Tsuji Y, Nakagawa T, Hatanaka M, et al. Quantification of caveolin isoforms using quantitative real-time RT-PCR, and analysis of promoter CpG methylation of caveolin-lalpha in human T cell leukemia cell lines[J]. Int J Mol Med, 2006, 18 (3) : 489-495.
  • 9Ono K, Iwanaga Y, Hirayama M, et al. Contribution of caveolin- lalpha and Akt to TNF-alpha-induced cell death[J]. Am J Physiol Lung CellMolPhysiol, 2004, 287: L201-209.
  • 10Felicetti F, Parolini I, Bottero L, et al. Caveolin-1 tumor-promoting role in human melanoma[J]. Int J Cancer, 2009, 125 (7): 1514-1522.

二级参考文献45

  • 1周永宁,徐采朴,韩彪,姬瑞.胃癌E-cadherin基因启动子CpG岛甲基化的研究[J].癌症,2005,24(10):1220-1224. 被引量：9
  • 2Parton RG. Cell biology. Life without caveolae. Science,2001,293 ( 5539 ) : 2404-2405.
  • 3Anderson RG, Jacobson K. A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains. Science ,2002, 296 (5574) : 1821-1825.
  • 4Carver LA, Schnitzer JE. Caveolae: mining little caves for new cancer targets. Nat Rev Cancer,2003,3(8) :571-581.
  • 5Hirasawa Y, Anti M, Imazeki F, et al. Methylafion status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma. Oncology, 2006, 71 ( 1-2 ) :77-85.
  • 6Racine C, Belanger M, Hirabayeshi H, et al. Reduction of caveolin 1 gene expression in lung carcinoma cell lines. Biochem Biophys Res Commun, 1999,255 (3) :580-586.
  • 7Hino M, Doihara H, Kobayashi K, et al. Caveolin-1 as tumor suppressor gene in breast cancer. Surg Today, 2003, 33 (7) :486- 490.
  • 8Yoo SH, Park YS, Kim HR, et al. Expression of caveolin-1 is associated with poor prognosis of patients with squamous cell carcinoma of the lung. Lung Cancer, 2003,42 ( 2 ) : 195-202.
  • 9Kato K, Hida Y, Miyamoto M, et al. Overexpression of caveolin- 1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage. Cancer, 2002,94(4) :929- 933.
  • 10Joo HJ, Oh DX, Kim YS, et al. Increased expression of caveolin- 1 and microvessel density correlates with metastasis and poor progrosis in clear cell renal cell carcinoma. BJU Int, 2004, 93 (3) .291-296.

共引文献21

同被引文献14

  • 1Senetta R, Stella G, Pozzi E, et al. Caveolin-1 as a promoter of tumour spreading: when, how, where and why[J]. J Cell Mol Med, 2013,17(3):325-336.
  • 2Mo S], Yang SL, Cui Z. New glimpses of caveolin-1 functions in embryonic development and human diseasea[J]. Front Biol, 2011, 6 (5):367-376.
  • 3GoetzJG, Lajoie P, Wiseman SM, et al. Caveolin-1 in tumor pro? gression: the good, the bad and the ugly[J]. Cancer Metastasis Rev, 2008,27(4):715-735.
  • 4Schlegel A, Arvan P, Lisanti MP. Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the endoplasmic reticulumm.J Biol Chem, 2001, 276(6):4398-4408.
  • 5Sunaga N, Miyajima K, Suzuki M, et al. Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer[J], Cancer Res, 2004, 64(12) :4277-4285.
  • 6Shi L, Chen XM, Wang L, et al. Expression of caveolin-1 in mucoepidermoid carcinoma of the salivary glands: correlation with vascular endothelial growth factor, microvessel density, and clinical out? come[J], Cancer, 2007, 109(8):1523-1531.
  • 7Xia X, Ma Q. Li X, et al. Cytoplasmic p21 is a potential predictor for cisplatin sensitivity in ovarian cancer[J]. BMC Cancer, 2011,11:399.
  • 8Saifo MS, Rempinski DJ, Rustum YM, et al. Targeting the oncogen? ic protein beta+carenin to enhance chemotherapy outcome against solid human cancers[J], Mol Cancer, 2010, 9:310.
  • 9Lu Z, Ghosh S, Wang Z, et al. Downregulation of caveolin-1 function by EGF leads to the loss of E-aldherin, increased transcription? al activity of beta-catenin, and enhanced tumor cell invasion[J]. Cancer Cell, 2003, 4(6):499-515.
  • 10Masuelli L, Budillon A, Marzocchella L, et al. Caveolin-1 overexpression is associated with simultaneous abnormal expression of the Ee-cadherin/o-B catenins complex and multiple erbb receptors and with lymph nodes metastasis in head and neck squamous cell carcinomasm.J Cell Physiol, 2012, 227(9):3344-3353.

引证文献1

二级引证文献2

癌变．畸变．突变
2012年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部