细胞因子在重症急性胰腺炎合并急性肺损伤中的作用

Role of cytokines in severe acute pancreatitis with acute lung injury

急性肺损伤(acute lung injury,ALI)是重症急性胰腺炎(severe acute pancreatitis,SAP)最常见、也是最早出现的并发症之一,死亡率极高,其病理生理机制尚未明确。近年来研究发现,肿瘤坏死因子-α(tumor necrosis factor-α,TNF-a)、白细胞介素-1(interleukin-1)、IL-6等细胞因子,通过彼此的相互作用和影响,在SAP合并ALI中起到至关重要的作用。文中就各种细胞因子在SAP合并ALI中的作用做一综述。

Acute lung injury（ALI） is one of the most common complications of severe acute pan-creatitis（SAP）,with a high mortality and unknown pathophysiological mechanisms.Recent studies show that such cytokines as tumor necrosis factor-α,interleukin-1,and interleukin-6,play a key role in SAP with ALI through interactions.