益气补肾祛瘀法治疗肝功能失代偿的原发性肝癌的临床研究

Clinical research on treatment of liver decompensation of primary liver cancer by the method of Yiqibushenquyu

目的观察益气补肾祛瘀法对肝功能失代偿的原发性肝癌的临床疗效和安全性。方法将纳入病例随机分为治疗组30例,对照组30例,两组均给予保肝降酶、抗病毒等常规治疗,治疗组在常规治疗的基础上口服益气补肾祛瘀中药。结果治疗组总有效率60.00%,对照组33.33%;治疗后治疗组平均生存期19.00个月,对照组9.13个月;治疗组在改善乏力等临床症状,提高白蛋白、降低胆红素等肝功能指标及提高AFP阴转率方面优于对照组。以上指标两组比较均有统计学意义。结论对肝功能失代偿的原发性肝癌患者,益气补肾祛瘀法能更好地缓解病情,延长生存期。

Objective To observe the clinical efficacy and the safety of Yiqibushenquyu for liver decompensation of primary liver cancer. Methods 60 cases were randomly divided into experimental group （30 cases） and control group （30 cases）. Both groups were given conventional treatment of hepatoprotective anti-virus and symptomatic treatment. Besides the conventional treatment, the experimental group was also given the Chinese medicine of Yiqibushenquyu. Results The total efficacy rate was 60.00% in the experimental group and 33.33% in the control group. After the treatment, patients survived for 19.00 months on average in the experimental group and 9. 13 months in the control group. More satisfied efficacy was found in modifying fatigue, increasing albumin, lowering bilirubin, and improving AFP negative conversion in the experimental group. All differences in the above indicators were significant between the two groups. Conclusion The method of Yiqibushenquyu can reduce patients＇ pain, improve liver function, and pro- long patients＇ survival.