蒲黄消炎颗粒急性毒性试验

Study of acute toxicity of puhuang antiphlogosis granule

目的:评价蒲黄消炎颗粒的急性毒性,为畜用临床剂量的设计提供依据。方法:蒲黄消炎颗粒按原生药4 g/mL的浓度及40 mL/kg的给药容量,24 h内给昆明种小鼠灌胃1次,连续观察14 d内小鼠的体重,毒性反应及死亡情况。结果:给药组和对照组小鼠在第1、7、14天的体重并无差异;小鼠无死亡,也无明显中毒反应,测得蒲黄消炎颗粒最大耐受量(MTD)为原生药160 g/kg(成人临床拟用量的333倍)。结论:蒲黄消炎颗粒在临床常用剂量下是安全的。

Objective： To evaluate the acute toxicity of Puhuang antiphlogosis granule, for veterinary clinical doses of designed. Methods： Mice were administered with fluid extract of Puhuang antiphlogosis granule for once per day, consecutively observing the body weight, toxic reaction and death of mice during 14 days. Results： There was no significant difference between the body weight of mice in the group of fluid extract and control （ P 〉 0.05 ） ; the maximum tolerated dose （MTD） of Puhuang antiphlogosis granule on mice is 160. 0 g/kg （333 times of clinical adult daily dose） . Conclusion： Puhuang antiphlogosis granule is safe in the usual clinical dose.