对氧磷酶1基因Q192R多态性和缺血性脑卒中关系的系统评价

A systematic review on the relationship of PON1 Q192R and ischemic stroke

目的:使用系统评价方法评价对氧磷酶1基因Q192R多态性与缺血性脑卒中的关系。方法:广泛检索了中英文数据库以发现合格研究,使用随机或固定效应模型计算合并比值比(OR值),使用Q检验评估研究之间异质性,使用Egger's(埃格)检验和漏斗图评估发表偏倚。结果:总共23个研究纳入Meta分析,发现在所有人群中,对氧磷酶1基因Q192R多态性R等位基因或RR基因型增加了缺血性卒中发病风险(192 R等位基因:OR:1.21,95%CI:1.08～1.35,P=0.0009;192 RR基因型:OR:1.25,95%CI:1.06～1.49,P=0.009)。结论:现有的证据表明,Q192 R多态性(主要是R等位基因和RR基因型)增加了缺血性卒中的发病风险,该结论需大样本进一步研究验证。

Objective：This study aimed to evaluate the association between the paraoxonase 1 （PON1） gene Q192R variants and is- chemic stroke by using a systematic review with meta-analysis. Methods： Relevant studies were identified by searching English and Chinese databases extensively. Allele and genotype frequencies for each included study were extracted. The odds ratio （OR） was cal- culated using a random-effects or fixed-effects model. Q statistic was used to evaluate homogeneity,and Egger＇s test and Funnel plot were used to assess publication bias. For family - based association studies,a descriptive analysis was carried out. Results： A total of 23 studies were identified for meta-analysis. It was found that the R allele or RR genotype of PON1 Q192 R polymorphism had an in- creased risk for ischemic stroke in the general population （ 192 R allele ： OR ： 1.21,95% CI ： 1.08 - 1.35, P = 0. 0009 and 192 RR genotype： OR： 1.25,95% CI： 1.06 - 1.49,P = 0. 009 in general population,respectively）. Conclusions： Existing evidence indicates that the Q192R polymorphism （the R allele and RR genotype） is associated with an increased risk of ischemic stroke in the general population. Future studies with larger sample sizes will be necessary to confirm the present results.