缺氧诱导因子HIF-1α在食管癌中的表达和微血管密度MVD的关系

Expressions of HIF-1α in esophageal cancer and relationship with angiogenesis

目的:研究缺氧诱导因子HIF-1α在食管癌中的表达,及其与肿瘤血管生成之间的关系。方法:选取43例食管癌和10例癌旁组织,运用免疫组化方法,采用HIF-lα单克隆抗体检测缺氧诱导因子HIF-1α的表达,以及CD34单克隆抗体测定间质微血管密度(MVD)。结果:HIF-1α在大多数食管癌细胞质中表达,HIF-1α的表达和肿瘤的浸润深度以及远处转移呈正相关,与肿瘤的MVD呈正相关。结论:HIF-1α的表达与食管癌的浸润及淋巴结转移有关,其机制可能与HIF-1α过度表达促进肿瘤血管的生成相关。

Objective：To detect the expression of HIF-1α as study well as its relationship with angiogenesis in esophageal cancer.Methods： The expressions of HIF-1α in 10 normal tissues and 43 esophageal cancer were detected by using immunohistochemisty,and stromal microvessel density（MVD） was counted according to the results of CD34 by using immunohistochemisty.Results：The majority of esophageal cancer expressed HIF-1α in the cytoplasm.There was positive correlation between HIF-1α expression in the cytoplasm and tumor infiltration depth.Expression of HIF-1α was positively correlated with MVD in immunoreation.Conclusion：HIF-1α may play an important role in angiogenesis and tumor progression by regulating the tumor angiogenesis in esophageal cancer