分次小剂量奈达铂联合氟尿嘧啶治疗晚期食管癌的临床观察

Clinical observation of multiple low doses of nedaplatin(NDP) combined with continuous intravenous infusion of 5-fluorouracil(5-FU) in the treatment of advanced esophageal cancer

目的:观察分次小剂量奈达铂(NDP)联合5-氟尿嘧啶(5-FU)持续静滴治疗晚期食管癌的近期疗效及不良反应。方法:将55例晚期食管癌患者随机分入实验组和对照组,实验组28例,给予NDP 20mg/m2静脉滴注,d1-5,5-FU 1.5/m2,化疗泵持续静脉输注120小时;对照组27例,给予NDP 100mg/m2静脉滴注,d1,5-FU用法同实验组。两组均21天为1周期。结果:实验组总有效率为(46.4%),对照组总有效率为(51.9%),两组比较无显著性差异(P>0.05)。实验组骨髓抑制的发生率明显低于对照组(P<0.05),消化道毒性及肾毒性两组无明显差异。结论:分次小剂量NDP联合5-FU持续滴注治疗晚期食管癌疗效确切,骨髓抑制及消化道反应均较轻,患者耐受良好。可考虑分次小剂量NDP给药方法替代常规奈达铂的用法。

Objective：To observe the short-term efficacy and adverse reaction of multiple low dose of nedaplatin（NDP） combined with continuous intravenous infusion of 5-fluorouracil（5-FU） in the treatment of advanced esophageal cancer.Methods： Fifty-five patients with advanced esophageal cancer were divided into experimental group and control group randomly.The experimental group,with 28 cases,was given NDP 20 mg/m2,intravenous drip,d1-5,5-FU 1.5/m2,continuous infusion for 120 hours,with chemotherapy pump;the control group with 27 cases was given NDP 100mg/m2,intravenous drip,d1,the usage of 5-FU was the same as the experimental group.Both 5-FU groups were treated every 21 days as a cycle.Results： The total effective rate of the experimental group was（46.4%）,the control group was（51.9%）,there was no significant difference between two groups（P 0.05）.The rate of myelosuppression of the experimental group was lower than that in the control group,the difference was significant（P0.05）,the rates of alimentary canal toxicity and nephrotoxicity had no significant differences between the two groups.Conclusion： Multiple low doses of nedaplatin（NDP） combined with continuous intravenous infusion of 5-fluorouracil（5-FU） in the treatment of advanced esophageal cancer is effective,myelosuppression and gastrointestinal reaction are mild,patients can tolerate it well.Multiple low doses of nedaplatin can be considered to replace the normal usage of nedaplatin（NDP）.