原发性肝癌TACE介入治疗60例分析

Summary analysis of TACE interventional treatment of primary liver cancer

目的:总结分析经动脉超选择化疗栓塞(TACE)治疗肝癌后肝CT分级、碘油沉积与临床疗效间关系。方法:原发性肝癌TACE病人60例。术前进行肝CT分级,术后复查甲胎蛋白(AFP)及CT,独立盲法评价碘油沉积情况,并随访病人生存状况。结果:CT分级1级和2级合并组与3级和4级之间差异显著,经log-rank检验,三条生存曲线之间差异有统计学意义(P=0.000),两两之间差异均有统计学意义。碘油沉积与疗效有密切相关性,经检验呈明显相关(P<0.01)。CT分级与碘油充填程度呈负相关(相关系数为-0.49,P<0.05)。结论:CT保留肝容积率及肝硬化CT分级在介入手术前对评估肝脏储备功能和预后有一定价值。碘油沉积与疗效关系密切,沉积越密实,临床疗效越好,这与其他国内外学者研究结果基本一致;CT分级与碘油充填程度呈负相关,呈线性关系。

Objective：To summarize the relation of superselective transcatheter arterial chemoembolization（TACE） therapy for liver cancer and liver CT grading,lipiodol deposition,clinical efficacy.Methods：Total of 60 cases were treated by TACE with primary liver cancer.Results：Significant difference between CT grade 1-2 group and 3-4 was found.Lipiodol deposition and efficacy was closely related,（P0.01）;CT grading and lipiodol filling degree was negatively correlated（P0.05）.Conclusion：CT reserves the liver volume rate and cirrhosis of the liver CT grading involved in pre-operative assessment of liver function and prognosis;lipiodol deposition and efficacy is closely related,CT grading and degree of iodized oil filling was negatively related.