survivin、Ki-67在胃肠间质瘤中的表达及其相互关系

Expression of survivin and Ki-67 in gastrointestinal stromal tumors and its clinical implication

目的:探讨survivin蛋白、增殖相关抗原Ki-67在不同恶性度胃肠间质瘤(GIST)中的表达及意义。方法:采用免疫组化SP法检测78例胃肠道间质瘤组织中survivin、Ki-67蛋白的表达,并分析其在不同性质的GIST中的表达差异。结果:78例GIST中,survivn、Ki-67蛋白的阳性表达率分别为69.2%和38.5%。Ki-67在胃肠间质瘤组中的表达高于在正常对照组中的表达,survivin,Ki-67蛋白在低度恶性、中高度恶性的GIST中的表达有显著差异(P<0.05)。在GIST肿瘤组织中survivin与Ki-67表达强度具有显著的正相关(rs'=0.57)。结论:survivin和Ki-67可能协同作用于GIST的发生发展,surivin和Ki-67蛋白对判断GIST的性质具有重要意义。

Objective： To investigate the expression of survivin and Ki-67 protein in gastrointestinal stromal tumors（GIST） and its clinical significance.Methods： The expression of survivin and Ki-67 protein were detected in 78 cases of GIST by immunohistochemical technique.The relationship between expression of survivin and Ki-67 protein and the clinicopathological factors of GIST was analyzed.Results： The positive expression rates of survivin and Ki-67 protein in GIST were 69.2% and 38.5% respectively,the difference of positive expression rate of survivin and Ki-67 protein was significant among benign,borderline and malignant GISTs（P 0.05）.There was significant correlation between survivin and Ki-67（rs′= 0.57）.Conclusion： Survivin and Ki-67 may play synergistic effect in the pathogenesis of GIST.The expression of survivin and Ki-67 protein are important predicting markers for differentiation degree of GIST.