摘要
目的建立骨-肌腱结点愈合过程的动物模型并进行MRI观察。方法用12只新西兰大白兔分别行兔髌骨部分切除后，再行髌腱结合术，于术后2周、4周、8周、12周进行大体和MRI检查。结果大体和MRI检查动态显示术后2、4、8、12周骨-肌腱结合部组织愈合过程，该过程以松质骨再生和骨-肌腱愈合接点纤维软骨带的再生为特征，随着时间的增长逐渐恢复。结论经改良的动物模型不影响骨-肌腱结点愈合，有利于MRI的正确观察。
Objective To establish a new bone-tendon junction injury animal models for better observation with MRI. Methods The patella of 12 mature New Zealand white rabbits were partially resected and then the tendon were sutured to bone.General examination and MRI were done after 2, 4, 8 and 12 weeks. Results The general examination and MRI results showed the healing process of bone-tendon junction dynamically in 2, 4, 8, 12 weeks after operation. The process was featured as cancellous bone regeneration and bone - tendon healing contact fibrocartilage zone regeneration, which was restored gradually as time pasted. Conclusions The modified animal models do not affect bone-tendon junction healing and is better for MRI observation correctly.
出处
《实验动物与比较医学》
CAS
2012年第6期489-492,共4页
Laboratory Animal and Comparative Medicine
基金
国家自然科学基金项目（30973067）、广州市医药卫生科技项目（201102A213159）、广州市卫生局重点项目（201102A212003）
