期刊文献+

血清NF-κB和p53在急性冠脉综合征中表达的研究

下载PDF
导出
摘要 目的探讨核因子κB(NF-κB)和抑癌基因p53在急性冠脉综合征(ACS)发生、发展中的意义。方法采用酶联免疫法(ELISA)检测ACS患者72例和健康对照组65例血清中NF-κB和p53的表达水平。结果与对照组比较,实验组NF-κB和p53均升高,差异有统计学意义(P<0.05)。结论 NF-κB和p53可能参与ACS的发生、发展。
出处 《重庆医学》 CAS CSCD 北大核心 2012年第34期3643-3644,共2页 Chongqing medicine
  • 相关文献

参考文献2

二级参考文献56

  • 1Herbst RS, Heymach Jg, Lippman SM. Lung cancer. NEngl J Med 2008; 359:1367-1380.
  • 2Finco TS, Westwick JK, Norris JL et al. Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation. J Biol Chem 1997; 272:24113-24116.
  • 3Hanson JL, Hawke NA, Kashams D, Baldwin AS. The nuclear factor kappaB subunits RelAJp65 and c-Rel potentiate but are not required for Ras-induced cellular transformation. Cancer Res 2004; 64:7248-7255.
  • 4Tergaonkar V, Perkins ND. p53 and NF-kappaB crosstalk: IKKalpha tips the balance. Mol Cell 2007; 26:158- 159.
  • 5Rocha S, Campbell KJ, Perkins ND. p53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor. Mol Cell 2003; 12:15-25.
  • 6Rocha S, Martin AM, Meek DW, Per- kins ND. p53 represses cyclin Dl transcription through down regulation of Bcl-3 and inducing increased asso- ciation of the p52 NF-kappaB subunit with histone deacetylase 1. Mol Cell Biol 2003; 23:4713-4727.
  • 7Meylan E, Dooley AL, Feldser DM, et al. Requirement for NF-kappaB signal- ling in a mouse model of lung adenocarcinoma. Nature 2009; 462:104-107.
  • 8Folkman J, Ryeom S. Is oncogene addiction angiogenesis-dependent? Cold Spring Harb Symp Quant Biol 2005; 70:389-397.
  • 9Weinstein IB. Cancer: addiction to oncogenes-the Achilles heal of cancer. Science 2002; 297:63-64.
  • 10Ehrenreiter K, Kern F, Velamoor V et al. Raf-1 addiction in Ras-induced skin carcinogenesis. Cancer Cell 2009; 16:149-160.

共引文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部