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冠心病患者血浆Apelin水平变化及其与心功能的相关性 被引量：4

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摘要 目的观察不同类型冠心病(CHD)患者血浆Apelin水平变化,探讨Apelin与CHD病变程度及心功能的相关性。方法选择76例急性冠脉综合征(ACS)患者作为ACS组,选择门诊治疗的稳定型心绞痛及无症状心肌缺血患者82例作为稳定型CHD组,健康体检者108例作为对照组(NC组)。采用酶联免疫吸附法(ELISA)测定3组人群血浆Apelin含量。同时测定心肌肌钙蛋白Ⅰ(CTNⅠ)及B型利钠尿肽(BNP)作为检测指标。结果 CHD各组Apelin浓度均降低,与对照组比较差异均有统计学意义(P<0.05)。ACS组低于稳定型CHD组Apelin水平,差异有统计学意义(P<0.05)。CHD患者Apelin浓度与CTNⅠ及BNP呈负相关(P<0.05),与患者的年龄、空腹血糖(FBG)、血脂及肾功能等均无明显相关性(P>0.05)。结论 CHD患者Apelin水平与心肌受损程度及心功能具有相关性,提示其可能作为评价CHD患者预后的一种生化指标。
作者 李丽英 王伟 魏雪梅 朱洁莹 张世勤 赵瑞芳
机构地区 河北省邯郸市第一医院心内科 河北省邯郸市第四医院内科
出处 《重庆医学》 CAS CSCD 北大核心 2012年第34期3646-3648,共3页 Chongqing medicine
关键词 APELIN 冠心病 发病机制
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献10

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同被引文献28

  • 1和亚萍,魏盟.Apelin在心血管系统的研究进展[J].国际心血管病杂志,2007,34(5):359-362. 被引量：3
  • 2Tang H, Sebastian B M, Axhemi A,et al. Ethanol-induced oxidative stress via the CYP2EI pathway disrupts adiponectin secretion from adipocytes[ J] .Alcohol Clin Exp Res,2012,36( 2 ) :214-222.
  • 3Addabbo F, Nacci C, De Benedietis L, et al. Gtobular adiponeetin counteracts VCAM-l-mediated monocyte adhesion via AdipoR1/ NF-κB/COX-2 signaling in human aortic endothelial cells[J]. Am J Physiol Endocrinol Metab, 2011,301 ( 6 ) : E1143-E1154.
  • 4张明,童静,应斌宇,唐疾飞,练红,范小芳,龚永生,杨鹏麟.冠心病患者血浆apelin水平的变化[J].实用医学杂志,2007,23(21):3361-3362. 被引量：7
  • 5Gijsberts CM,Gohar A,Ellenbroek GHJM,et al.Severity of stable coronary artery disease and its biomarkers differ between men and women undergoing angiography[J].Atherosclerosis,2015,241(1):234-240.
  • 6Flores-Blanco PJ,Januzzi JL,Marin F,et al.Major bleeding risk prediction using chronic kidney disease epidemiology collaboration and modification of diet in renal disease equations in acute coronary syndrome[J].Eur J Clin Invest,2015,45(4):385-393.
  • 7Doganer Y覶,Aydogan譈,Rohrer JE,et al.Comparison of estimated GFR equations based on serum cystatin C alone and in combination with serum creatinine in patients with coronary artery disease[J].Anatol J Cardiol,2015,15(7):571-576.
  • 8Shafranskaya KS,Kashtalap VV,Gruzdeva OV,et al.The role of cystatin C in the prognosis of adverse outcomes after the coronary artery bypass graft surgery during hospitalisation[J].Heart Lung Circ,2015,24(2):193-199.
  • 9无.急性ST段抬高型心肌梗死诊断和治疗指南[J].中华心血管病杂志,2010,38(8):675-690. 被引量：1951
  • 10焦路阳,袁彬,袁晓梅,孙浩杰,袁宇5.血清内脂素、脂联素和C-反应蛋白与冠状动脉病变的相关性[J].新乡医学院学报,2012,29(8):600-602. 被引量：10

引证文献4

二级引证文献6

重庆医学
2012年 第34期

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